Blood transfusions Flashcards Preview

Block 6 > Blood transfusions > Flashcards

Flashcards in Blood transfusions Deck (40):
1

enzyme for A type

N-acetylgalactosamine

2

enzyme for B type

galactose

3

RhoGAM

prevents anti-D antibodies from being produced in an RhD negative women if the baby is Rh +

4

major indications for transfusing RBC

acute anemia- acute loss, hemolysis, aplastic crisis
chronic anemia- chemo, renal failure

5

major indications for platelet transfusion

thrombocytopenia with bleeding
prophylaxis for thrombocytopenia without bleeding
platelet function disorders

6

signs for transfusion by platelet count

>20k spontaneous bleeding (rare)
10k- stable thrombocytopenia oncology patients
>50k active bleeding
>100k neurosurgery

7

contraindicated to give platelets to

DIC
ITP
TTP
HIT

8

fresh frozen plasma

replaces clotting factors

9

fresh frozen plasma indication

DIC
liver disease
massive transfusion
isolated factor deficiency
TTP
reverse warfarin effects

10

PT/PTT guidance for FFP transfusion

>1.5 normal

11

cryoprecipitate

collected precipitate from FFP
F8, fibrinogen, vWF, F13

12

blood typing

ABO and RhD status

13

front type

monoclonal antibodies for A, B, D to look for antigens on the RBC

14

back type

look for expected antiA antiB in the plasma

15

blood screen

look for unexpected antibodies in the plasma

16

hemolytic disease of new born

mom's IgG antibodies cross placenta and cause hemolysis in fetus

17

crossmatch

check patient's plasma with transfusion unit

18

P antigen

parvovirus B19

19

mononucleuosis

cold agglutinins against i antigen

20

I antigen

mycoplasma pneumonia- cold agglutinins

21

Duffy

receptor for plasmodium vivax

22

hemolytic tx reaction

ABO incompatibility
fever, back pain
stop the transfusion
leads to intravascular hemolysis and DIC

23

febrile tx reaction

cytokines from leukocytes accumulate in stored blood
fever, shaking chills
stop transfusion and treat symptoms

24

prevention of febrile tx rx

remove WBC

25

allergic tx rx

hypersensitivity to allergen in it
IgE mediated
parities, urticaria

26

TRALI

transfusion related acute lung injury
tachypnea, cyanosis, dyspnea, fever, hypoxemia
HLA or granulocyte antibodies react with patients white cells leading to aggregates

27

prevention of TRALI

don't use products with anti-HLA antibodies

28

TACO

transfusion associated circulatory overload
fluid overload from blood products causes cardiac failure and pulmonary compromise
increased BNP

29

GVHD

antibodies in the transfusion attack host cells

30

symptoms of GVHD

8-10d post transfusion
pancytopenia with marrow aplasia
fever
rash
mucositis, NVD
hepatitis

31

higher risk GVHD with

similar HLA types

32

prevention of GVHD

irradiation- inactivates T lymphocytes

33

septic tx rx

bacteria in transfusion product

34

prevention septic rx

test for bacteria

35

lab test for HIV

anti HIV1/2
PCR

36

lab test for HCV

antiHCV
PCR

37

lab test for hepatitis B

HBsAg
antiHBc
PCR

38

lab test for HTLV

antiHTLV1/2

39

lab test for spyphilis

PCR

40

lab test for west nile

PCR