Anxiolytics Flashcards Preview

Block 6 > Anxiolytics > Flashcards

Flashcards in Anxiolytics Deck (54):
1

symptoms of anxiety

restlessness
tachycardia
sweating
insomina

2

brain structures involved in anxiety

hippocampus
amygdala

3

uses of anxiolytic drugs

anesthesia
anxiety and psychiatric disorders
acute anxiety
alcohol and other drug withdrawal

4

classes of anxiolytic drugs

barbiturates
benzodiazepines
buspirone
antidepressants

5

antidepressants used for anxiety

SSRI
SNRI
TCA
MAOI

6

first choice drugs for anxiety

SSRI
SNRI

7

benzos bind to GABA receptors and

increase frequency of opening

8

barbiturates bind to GABA receptors and

increase duration of opening

9

flumazenil

bento antagonist used for OD of benzos

10

limitations of flumazenil

doesn't work for alcohol, barbiturate, or other anesthetic overdoses

11

clonazepam

benzo with slower onset of action
used to treat withdrawal from benzos

12

active metabolite of some benzos

desmethyldiazepam
formed by phase 1 oxidation at liver

13

benzo excretion

phase 2 glucuronidation and excreted by kidneys

14

long acting benzos

converted to desmethyldiazepam
30-200h
chlordiazepoxide
diazepam
flurazepam

15

fluazepam

long acting benzo

16

chlordiazepoxide

long acting benzo

17

flurazepam

long acting benzo

18

short acting benzos

skips phase 1 oxidation
used for hypnotics
3-27h
alprazolam
lorazepam
oxazepam
temazepam

19

alprazolam

short acting benzo

20

lorazepam

short acting benzo

21

oxazepam

short acting benzo

22

temazepam

short acting benzo

23

ultra short acting bentos

1-5h
triazolam

24

triazolam

short acting benzo
best sleep aid

25

contraindications to benzo use

required mental alertness
alcohol, drug, substance abuse
pregnant
breast feeding

26

ADR of benzos

drowsiness
dizziness
ataxia
respiratory depression
disinhibition
rare- increased aggression, allergic reactions

27

risk factors of using benzos

impaired liver function, age
renal disease
COPD, sleep apnea
myasthenia gravis
history of substance abuse, cognitive disorders, CNS depression

28

risks associated with abruptly stopping benzos

rebound anxiety/insomina
withdrawal symptoms- paranoia, depression, suicidal ideation, delirium, seizures

29

worst class of drug for physical dependence

benzos

30

indications for benzo use (9)

GAD
panic
social anxiety
PTSD
acute stress
adjustment disorder with anxiety
bipolar
anxiety associated with life events
akathisia

31

benzo drug interactions

CYP interactions- increase plasma levels
rifampin and tobacco- decrease plasma levels
food and antacids- decrease absorption
additive with sedative and CNS depressants

32

buspirone MOA

5HT1a partial agonist
presynaptic dopamine antagonist
partial alpha1 agoinst

33

benefits of buspirone

no sedation, anticonvulsant, muscle relaxation
no tolerance or cross tolerance
no potential for addiction or dependance

34

buspirone use

chronic anxiety- takes days/weeks to see an affect
GAD

35

drugs for panic disorder

SSRI (gold standard)
TCA
SNRI
benzos- used to accelerate onset and reduce side effects of the antidepressants
MAOI- only if others don't work

36

GAD drugs

benzos
buspirone
SNRI
SSRI

37

SNRI for GAD

venlafaxine

38

SSRI for GAD

paroxetine
citalopram

39

SSRI for panic disorder

setraline
paroxetine

40

TCA for panic disorder

imipramine
clomipramine

41

SNRI for panic disorder

venlafaxine

42

benzos for panic disorder

alprazolam
clonazepam
lorazepam

43

drugs for social anxiety disorder

SSRI
bentos
beta blockers
antihistamines

44

SSRI for social anxiety disorder

sertraline
paroxetine
venlafaxine

45

beta blocker for social anxiety disorder

propranolol

46

antihistamines for social anxiety disorder

diphenhydramine
hydroxyzine

47

drugs for OCD

TCA
SSRI

48

drugs that do not work for OCD

buspirone
other TCAs
MAOI
buproprione

49

TCA for OCD

clomipramine

50

SSRI for OCD

sertraline
paroxetine
fluoxetine
fluvoxzamine

51

drugs for PTSD

SSRI- first line
bentos
TCA, SNRI, MAOI
adrenergic inhibitors

52

trazadone

for PTSD
augments SSRI effectiveness and reverses insomnia and sedation

53

adrenergic inhibitors for PTSD

alpha2 agonists
clonidine
guanfacine

54

effects of adrenergic inhibitors for PTSD

reduces hyperactivity, nightmares, startle, rage, hyper vigilance