Bipolar Drugs Flashcards Preview

Block 6 > Bipolar Drugs > Flashcards

Flashcards in Bipolar Drugs Deck (25):
1

3 classes of treatment

litium
anticonvulsants
atypical antipsychotics

2

first line bipolar

lithium

3

MOA lithium

not known
increases hippocampal and amygdala volume

4

therapeutic range Li

0.5-1.0

5

effects of >1.5 Li

tremor
nausea
diarrhea

6

effects of >2 Li

neurotoxicity
delirum

7

effects > 3 Li

fatal

8

Li clearance

renal
affected by diuretics and anti-inflammatory drugs

9

mild side effects Li

headache
fatigue
confusion
thirst
polyuria
weakness

10

severe side effects Li

monoclonal jerks
seizures
impaired consciousness
coma
death

11

cardiac effects of Li

EKG irregularities
cardiac arrest

12

Li contraindications

pregnant
breastfeeding

13

effects of Li on fetus/baby

floppy baby syndrome
fetal goiter
Epstein's abnormality
arrhythmias

14

second line bipolar drugs

anticonvulsants

15

carbamazepine

first gen anticonvulsant
stabilizes inactive voltage gated Na channels
GABA receptor agoinst

16

lamotrigine

second gen anticonvulsant
stabilizes inactive voltage gated Na channels

17

valproate

anticonvulsant
unknown MOA- enhances GABA function to decrease neuronal firing

18

atypical antipsychotics

positive and negative symptoms of schizophrenia
act on 5HT2a receptors

19

atypical antipsychotics for bipolar

aripiprazole
ziprasidone
resperidone
asenapine
quetiapine
olanzapine

20

aripiprazole

atypical antipsychotic

21

ziprasidone

atypical antipsychotic

22

resperidone

atypical antipsychotic

23

asenapine

atypical antipsychotic

24

quetiapine

atypical antipsychotic

25

olanzaine

atypical antipsychotic