WBC and associated changes Flashcards Preview

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Flashcards in WBC and associated changes Deck (45):
1

absolute WBC count

WBC * % cell type
quantitative measure

2

relative WBC count

% cell type
depends on number of other line

3

granulocyte

neutrophil
eosinophil
basophil

4

myeloperoxidase

neutrophil primary granule

5

alkaline phosphatase

neutrophil secondary granule

6

leukemoid reaction

elevated WBC with immature cells
20-50k neutrophils
indicates stress
Dohle bodies present

7

leukoerythroblastic blood picture

leukemoid WBC + elevated RBC
reactive, neoplastic, marrow disorder

8

neutrophilia

elevated neutrophils
bacterial infection
tissue necrosis
physiologic stress
hematologic disorders
drug reaction
metabolic

9

normal WBC count

5-10k

10

neutropenia

decreased neutrophils

11

causes of decreased marrow production of neutrophils

toxicity
aplastic anemia
myelophthisis
nutritional deficiency
collagen diseases

12

causes of increased destruction/use of neutrophils

splenic sequestration
viral infections
immune mediated
prolonged inflammation

13

drugs associated with neutropenia

antibiotics

14

monocyte main function

phagocytosis

15

main cause of monocytosis

neutropenia
chronic inflammation
malignancy

16

eosinophil function

limit chronic inflammatory responses

17

eosinophil graunles

peroxidase
acid phosphatase

18

eosinophil membrane receptors

IgG
complement

19

causes of eosinophilia

parasite infection
allergy
drug reactions

20

chronic hypereosinophilic syndrome

persistent elevation in eosinophils
rare
needs to be treated early

21

basophil granules

histamine
heparin-like mucopolysaccharides

22

basophil membrane receptors

IgE

23

basophil function

hypersensitivity reactions

24

basophilia cause

myeloproliferative disorders- CML
hypersensitivity reactions

25

which is more b or t cells

T cells

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which lives longer b or t cells

T cells

27

b cell function

humoral immunity
antibody production

28

T cell function

cellular immunity
b cell inducer

29

mechanical interference with lymphocytes

thoracic duct obstruction
intestinal lymphatics with poor absorption

30

layers of the folicle

germinal center- CD10+
mantle- CD5+
marginal zone- CD5/10-

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precursor B lymphoblasts

precursor for entire b cell lineage
TdT

32

naive mature B cell

circulating in blood
primary follicle and mantle zone
sIg- M D
have not found antigen

33

germinal center blasts- b cells

found antigen, returned to germinal center secondary follicle
CD10, BCL6 +
BCL2 and sIg negative
IgM switch to IgG or IgA

34

CD10+

germinal center lymphocyte
found the antigen pair

35

BCL2

anti apoptosis
in all cells except centroblasts

36

germinal center centrocytes

secondary germinal center resting cells
sIg
BCL2 +
IgM or IgA

37

plasma cells

return to bone marrow
CD79a, CD138 +
BCL6, sIg, CD20, CD5, CD10 -
produces antibodies

38

memory B cells

go back to lymphoid organ origin
sIg, CD20, BCL2 +
BCL6, CD5, CD10 -
IgM

39

lymphocytosis of acute infections

infectious mono (EBV)
pertussis
other viruses

40

lymphocytosis

chronic infection
thyrotoxicosis
drug sensitivity
hematologic malignancy

41

lymphopenia

immunodeficiency syndromes
lymphocyte destruction
mechanical loss
neoplasms

42

monocyte granules

lysozyme

43

myeloid maturation

myeloblast
promyelocyte
myelocyte
metamyelocyte

44

CD20

memory b cell marker

45

CD138, CD79a

plasma cell marker