WBC and associated changes Flashcards by Christina Provenza

absolute WBC count

WBC * % cell type

quantitative measure

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relative WBC count

% cell type

depends on number of other line

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granulocyte

neutrophil
eosinophil
basophil

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myeloperoxidase

neutrophil primary granule

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alkaline phosphatase

neutrophil secondary granule

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leukemoid reaction

elevated WBC with immature cells
20-50k neutrophils
indicates stress
Dohle bodies present

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leukoerythroblastic blood picture

leukemoid WBC + elevated RBC

reactive, neoplastic, marrow disorder

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neutrophilia

elevated neutrophils
bacterial infection
tissue necrosis
physiologic stress
hematologic disorders
drug reaction
metabolic

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normal WBC count

5-10k

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neutropenia

decreased neutrophils

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causes of decreased marrow production of neutrophils

toxicity
aplastic anemia
myelophthisis
nutritional deficiency
collagen diseases

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causes of increased destruction/use of neutrophils

splenic sequestration
viral infections
immune mediated
prolonged inflammation

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drugs associated with neutropenia

antibiotics

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monocyte main function

phagocytosis

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main cause of monocytosis

neutropenia
chronic inflammation
malignancy

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eosinophil function

limit chronic inflammatory responses

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eosinophil graunles

peroxidase

acid phosphatase

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eosinophil membrane receptors

IgG

complement

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causes of eosinophilia

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parasite infection
allergy
drug reactions

chronic hypereosinophilic syndrome

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persistent elevation in eosinophils
rare
needs to be treated early

basophil granules

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histamine

heparin-like mucopolysaccharides

basophil membrane receptors

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IgE

basophil function

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hypersensitivity reactions

basophilia cause

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myeloproliferative disorders- CML

hypersensitivity reactions

which is more b or t cells

T cells

which lives longer b or t cells

T cells

b cell function

humoral immunity | antibody production

T cell function

cellular immunity | b cell inducer

mechanical interference with lymphocytes

thoracic duct obstruction | intestinal lymphatics with poor absorption

layers of the folicle

germinal center- CD10+ mantle- CD5+ marginal zone- CD5/10-

precursor B lymphoblasts

precursor for entire b cell lineage | TdT

naive mature B cell

circulating in blood primary follicle and mantle zone sIg- M D have not found antigen

germinal center blasts- b cells

found antigen, returned to germinal center secondary follicle CD10, BCL6 + BCL2 and sIg negative IgM switch to IgG or IgA

CD10+

germinal center lymphocyte | found the antigen pair

BCL2

anti apoptosis | in all cells except centroblasts

germinal center centrocytes

secondary germinal center resting cells sIg BCL2 + IgM or IgA

plasma cells

return to bone marrow CD79a, CD138 + BCL6, sIg, CD20, CD5, CD10 - produces antibodies

memory B cells

go back to lymphoid organ origin sIg, CD20, BCL2 + BCL6, CD5, CD10 - IgM

lymphocytosis of acute infections

infectious mono (EBV) pertussis other viruses

lymphocytosis

chronic infection thyrotoxicosis drug sensitivity hematologic malignancy

lymphopenia

immunodeficiency syndromes lymphocyte destruction mechanical loss neoplasms

monocyte granules

lysozyme

myeloid maturation

myeloblast promyelocyte myelocyte metamyelocyte

CD20

memory b cell marker

CD138, CD79a

plasma cell marker

WBC and associated changes Flashcards

(45 cards)