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Step One R&M > Autoantibodies > Flashcards

Autoantibodies Flashcards

1
Q

Goodpasture’s

A

Anti-BM

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1
Q

Anti-hemidesmosome

A

Bullous pemphigoid

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1
Q

p-ANCA

A

Anti-MPO

Microscopic polyangitis, Churg-Strauss

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2
Q

Type I DM

A

Anti-glutamate decarboxylase

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3
Q

Dermatomyositis, polymyositis

A

Anti-Jo, anti-SRP, anti-Mi-2

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4
Q

Celiac disease

A

IgA antiendomysial

IgA anti-tissue transglutaminase

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5
Q

MG

A

Anti-ACh receptor

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5
Q

Anti-dsDNA

A

SLE

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5
Q

Bullous pemphigoid

A

Anti-hemidesmosome

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6
Q

Causes of anti-histone antibodies in blood

A

Drug-induced lupus due to procainamide, hydralazine, and INH

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7
Q

Autoimmune hepatitis

A

Anti-smooth muscle

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8
Q

Anti-TSH receptor

A

Grave’s

(antibody STIMULATES receptor = hyperthyroidism)

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8
Q

Anti-MPO

A

p-ANCA

Microscopic polyangitis

Churg-Strauss

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9
Q

Anti-thyroglobulin

A

Hashimoto

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10
Q

What effect does lupus anticoagulant have on coagulation studies?

A

Falsely-elevated PTT

(but patient is acutally hypercoagulated)

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11
Q

Drug-induced lupus

A

Antihistone

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12
Q

Mixed connective tissue disease

A

Anti-U1 RNP

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13
Q

Anti-U1 RNP

A

Mixed connective tissue disease

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15
Q

Anti-ACh receptor

A

MG

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16
Q

IgA anti-tissue transglutaminase

A

Celiac disease

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17
Q

Graves disease

A

Anti-TSH receptor

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18
Q

Sjogren’s

A

Anti-Ro, anti-La

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19
Q

Anti-centromere

A

CREST

19
Q

Anti-La

A

Sjogren’s

20
Q

Antimicrosomal

A

Hashimoto

21
Q

IgA antiendomysial

A

Celiac disease

22
Q

c-ANCA

A

anti-PR3

Wegner’s

23
Q

Hashimoto

A

Anti-microsomal, anti-thyroglobulin

24
Q

Anti-IgG Fc

A

Rheumatoid factor

25
Q

SLE

A

Antinuclear antibodies, Anti-Smith, Anti-dsDNA, Anti-cardiolipin

27
Q

Scleroderma

A

Anti-DNA topoisomerase I

28
Q

Anti-CCP

A

RA

29
Q

What effect does anti-cardiolipin antibody have on syphilis testing?

A

False +

30
Q

Antimitochondrial

A

Primary biliary cirrhosis

31
Q

What is the clinical consequence of finding lupus anticoagulant in a patient’s blood?

A

Must be put on life-long anticoagulant

33
Q

Anti-desmoglein

A

Pemphigus vulagaris

34
Q

Anti-DNA topoisomerase I

A

Scleroderma

( = Scl-70 )

35
Q

Antihistone

A

Drug-induced lupus

36
Q

CREST

A

Anti-centromere

37
Q

Anti-Smith

A

SLE

38
Q

Churg Strauss

A

Anti-MPO/p-ANCA

40
Q

Anti-cardiolipin or lupus anticoagulant

A

SLE, antiphospholipid syndrome

41
Q

Pemphigus vulgaris

A

Anti-desmoglein

42
Q

What is the target of Sjogren antibodies?

A

Ribonucleoproteins

(anti-SSA, anti-SSB, anti-Ro, anti-La)

44
Q

Anti-smooth muscle

A

Autoimmune hepatitis

46
Q

Anti-Jo

A

Dermatomyositis, polymyositis

47
Q

Anti-PR3

A

cANCA

Wegner’s

48
Q

Most specific for SLE

A

Anti-dsDNA

49
Q

Primary biliary cirrhosis

A

Anti-mitochondrial

50
Q

Anti-BM

A

Goodpasture syndrome

51
Q

Wegner’s

A

c-ANCA/anti-PR3

52
Q

RA

A

Anti-CCP (specific), rheumatoid factor (IgM against Fc of IgG)

53
Q

Anti-Ro

A

Sjogren’s

54
Q

Anti-Mi-2

A

Dermatomyositis, polymyositis

55
Q

Anti-glutamate decarboxylase

A

Type I DM

56
Q

Anti-SRP

A

Dermatomyositis, polymyositis

Step One R&M (38 decks)

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