Anti-HBs + Anti-HBe + Anti-HBc IgG
Immunized to HBV serum
DNA hepatitis virus
(All others are RNA)
Where does CMV stay latent?
Chronic phase serum with low infectivity
Which DNA viruses are not linear?
Which DNA virus does not replicate in the nucleus nor has an icosahedral capsid?
(remember it's the largest virus = can carry its own DNA-dep RNA polymerase)
Owl eye inclusions
Waterborne epidemics, hepatitis
Requires another virus
HDV requires HBV
HBsAG + Anti-HBe + Anti-HBc IgG
Chronic infection with low infectivity
Fecal-oral hepatitis viruses
How do anti-HBV antibodies protect against hepatocellular damage?
Antibodies prevent viral entry into cells, so antigens can never be loaded onto MHC class I and presented to CD8+
Hepatits that's usually asymptomatic
Worse prognosis HDV
Co-infection with HBV
Chronic HBV serum with high infectivity
Anti-HBe + Anti-HBc IGM
Window period (5-6 months after infection)
High fevers for several days that can cause seizures followed by a maculopapular rash
Which virus gets its envelope from the nuclear membrane?
(All other enveloped virus get it from cytoplasmic membrane)
Better or worse prognosis? HDV after HBV
Better (Superinfection better than co-infection)
Acute phase serum HBV
Hepatitis with short incubation
Reoviridae (Coltivirus, Rotavirus)
Replicate in nucleus
DNA viruses (except pox virus)
High mortality in preggos, hepatitis
Which DNA virus is not ds?
Where do DNA viruses replicate?
(Except pox virus, which has its own polymerase)
Maternal-fetal hepatitis viruses
HBsAG + HBeAG + HBcAG IgM
Acute phase serum
(1-5 months after infection)
Most segmented viruses
Reoviruses (rotovirus, coltivirus) ith 10-12 segments
RNA flavivirus (hepatitis)
No carrier state, hepatitis
Where do RNA viruses replicate?
Cytoplasm (except flu and retroviruses)
Hepatitis virus that increases HCC risk due to chronic inflammation
Monospot negative mononucleosis
Least segmented virus
Arenavirus (LCMV, lassa fever encephalitis)
Hepatitis virus that increases HCC risk by incorporating into genome and acting as an oncogene
Kaposi sarcoma is a neoplasm of ____
Window period serum HBV
No HCC risk, hepatitis
HBsAg + HBeAg + Anti-HBc IgG
Chronic infection with high infectivity
Which naked nucleic acid particles would not be infectious?
dsRNA (Coltivirus, Rotavirus)
- ssRNA (Orthomyxoviruses, Paramyxoviruses, Rabies, Ebola, LCMV, Bunyaviridae, Hep D)
**These viruses carry their own polymerases so require in tact virions**
Cause of Roseola?
A person has anti-HBs in their blood but no anti-HBc. What do you know about this patient?
Which RNA viruses don't replicate in the cytoplasm?
RNA picornavirus (hepatitis)
(Blueberry muffin spots = extramedullary hematopoeisis)
All are RNA viruses:
Arenavirus (LCMV, Lassa fever)
Reovirus (rotavirus, coltivirus)
Recovery phase serum HBV