Bacterial Toxins Flashcards Preview

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Flashcards in Bacterial Toxins Deck (39):
1

TSST-1: organism

S. aureus

2

TSST-1: toxin type

superantigen

3

TSST-1: effects

toxic shock syndrome: fever, rash, shock

4

Scarlet fever-erythrogenic toxin: organism

S. pyogenes

5

Scarlet fever-erythrogenic toxin: effects

toxic shock-like syndrome

6

Scarlet fever-erythrogenic toxin: toxin type

superantigen

7

C. diptheria toxin: mechanism

ADP ribosylating A-B toxin: inactivates EF-2

8

C. diptheria toxin: effects

pharyngitis, pseudomembrane in throat

9

V. cholerae toxin: mechanism

ADP ribosylating A-B toxin: ribosylation of G protein upregulates adenylyl cyclase

10

V. cholerae toxin: effects

H2O moves out of cell: rice-water diarrhea

11

E. coli heat labile toxin: mechanism

ADP ribosylating A-B toxin: stimulates adenylate cyclase

12

E. coli heat labile toxin: effect

rice-water diarrhea

13

E. coli heat stable toxin: mechanism

ADP ribosylating A-B toxin simlates guanylate cyclase

14

E. coli heat stable toxin: effect

Rice water diarrhea

15

B. pertussis toxin: mechanism

ADP ribosylating A-B toxin: inhibits Galpha1, increases cAMP

16

B. pertussis toxin: effects

Whooping cough
lymphocytosis

17

alpha toxin: organism

C. perfringins

18

alpha toxin: effect

gas gangrene

19

C. tetani toxin: mechanism

blocks release of GABA and glycine

20

C. tetani toxin: effect

lockjaw

21

C. botulinum toxin: mechanism

blocks release of Ach

22

C. botulinum toxin: effect

anticholinergic symptoms, flaccid paralysis

23

Edema factor: organism

B. anthracis

24

Edema factor: mechanism

adenylate cyclase

25

Shiga toxin: mechanism

cleaves host rRNA, inactivates 60S ribosome, enhances cytokine release

26

Shiga toxin: effect

HUS

27

Streptolysin O: organism

S. pyogenes

28

Streptolysin O: mechanism

hemolysin

29

Streptolysin S: organism

S. pyogenes

30

Streptolysin S: mechanism

hemolysis

31

Erythrogenic/pyrogenic toxins: organism

S. Pyogenes

32

Erythrogenic/pyrogenic toxins: effect

skin rash and fever of scarlet fever

33

alpha toxin of S. aureus: effect

hemolysis

34

beta toxin of S. aureus: effect

sphingomyelinase

35

proteins A, B, and C of gamma-toxin of S. aureus: effects

A and B: hemolysin
B and C: leukocidin

36

hemolysin of S. aureus: effect

hemolysis

37

leukocidin of S. aureus: effect

destroys leukocytes

38

enterotoxins A-E of S. aureus: effect

food poisoning, vomiting and diarrhea

39

epidermolytic/exfoliative toxin of S. aureus: effect

epithelial cell lysis, scalded skin syndrome