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Flashcards in HAART Deck (18):
0

-navirs: type

Protease inhibitor

1

Protease inhibitors: mechanism

Block protease in progeny virions

2

Protease inhibitors: toxicities (4)

GI intolerance
Hyperglycemia
Lipodystrophy
Thrombocytopenia (indinavir)

3

Zidovudine: type

NRTI

4

Didanosine: type

NRTI

5

Zalcitabine: type

NRTI

6

Stavudine: type

NRTI

7

Lamivudine: type

NRTI

8

Abacavir: type

NRTI

9

Nevirapine: type

NNRTI

10

Etavirenz: type

NNRTI

11

Delavirdine: type

NNRTI

12

RTIs: mechanism

Preferentially inhibit reverse transcriptase of HIV, prevent incorporation of DNA copy of viral genome into host DNA

13

RTIs: toxicities (5)

Bone marrow suppression
Peripheral neuropathy
Lactic acidosis (NRTIs)
Rash (NNRTIs)
Megaloblastic anemia (ZDV)

14

Enfuvirtide: type

Fusion inhibitor

15

Enfuvirtide: mechanism

bind viral gp41 subunit, inhibit conformational change required for fusion with CD4 cells

16

Enfuvirtide: toxicities (3)

hypersensitivity reactions
reactions at subcutaneous injection site
increased risk of bacterial pneumonia

17

Enfuvirtide: clinical use

In patients who don't respond to other antiretrovirals