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Flashcards in Renal Tubules, drugs Deck (41):
1

Reabsorbs 67% of fluid and electrolytes filtered by glomerulus

Proximal Tubule

2

concentrates urine

collecting duct

3

site of secretion of organic anions and cations

proximal tubule

4

always impermeable to water

thick ascending limb

5

permeable to water only in presence of ADH

late distal tubule, collecting duct

6

Site of Na/K/2CL cotransporter

thick ascending limb

7

site of isotonic fluid reabsorption

proximal tubule

8

site responsible for diluting urine

thick ascending limb

9

site where glucose and amino acids are reabsorbed

proximal tubule

10

water reabsorption in loop of Henle

thin descending limb

11

Mannitol: mechanism

osmotic diuretic

12

Mannitol: location of action

PCT

13

Mannitol: toxicity (2)

pulmonary edema
dehydration

14

Mannitol: uses (3)

Shock, drug overdose, high ocular/cranial pressure

15

Acetazolamide: mechanism

Carbonic anydrase inhibitor; causes NaHCO3 diuresis, reduction in total-body HCO3- stores

16

Acetazolamide: location of action

PCT

17

Acetazolamide: toxicity (4)

hyperchloremic metabolic acidosis
neuropathy
NH3 toxicity
Sulfa allergy

18

Acetazolamide: uses (4)

Glaucoma
Urinary alkalinization
metabolic alkalosis
altitude sickness

19

Furosemide: mechanism

Inhibits Na/K/2Cl cotransporter

20

Furosemide: location

Loop of Henle, thick ascending limb

21

Furosemide: toxicity (6)

Ototoxicity
Hypokalemia
Dehydration
Allergy (sulfa)
Nephritis (interstitial)
Gout

22

Furosemide: uses (3)

Edema
HTN
Hypercalcemia

23

Ethacrynic acid: mechanism

Phenoxyacetic acid derivative, same as furosemide

24

Ethacrynic acid: location

Loop of Henle; thick ascending limb

25

Ethacrynic acid: 6 toxicities

Ototoxicity
Hypokalemia
Dehydration
Allergy (sulfa)
Nephritis (interstitial)
Gout

26

Ethacrynic acid: use

diuresis in sulfa-allergic patients

27

Hydrochlorothiazide: mechanism

Inhibits NaCl reabsorption

28

Hydrochlorothiazide: location

early distal tubule

29

Hydrochlorothiazide: toxicities (7)

Hypokalemic metabolic alkalosis
hyponatremia
hyperglycemia
hyperlipidemia
hyperuricemia
hypercalcemia
sulfa allergy

30

Hydrochlorothiazide: uses (4)

HTN
CHF
Idiopathic hypercalciuria
Nephrogenic diabetes insipidus

31

Spironolactone/Eplerenone:mechanism

K sparing diuretic; competitive aldosterone receptor antagonist

32

Spironolactone/Eplerenone: location

cortical collecting tubule

33

Spironolactone/Eplerenone: toxicities (2)

hyperkalemia
endocrine effects

34

Spironolactone/Eplerenone: uses (3)

hyperaldosteronism
K depletion
CHF

35

Triamterene/Amiloride: mechanism

K sparing diuretic; block Na channels

36

Triamterene/Amiloride: location

CCT

37

Triamterene/Amiloride: toxicity

Hyperkalemia

38

Triamterene/Amiloride: uses (3)

hyperaldosteronism
K depletion
CHF

39

Captopril/Enalapril/lisinopril: mechanism

ACE inhibitor

40

Captopril/Enalapril/lisinopril uses (3)

HTN
CHF
Diabetic renal disease

41

Captopril/Enalapril/lisinopril: toxicity (10)

Cough
Angioedema
Proteinuria
Taste changes
hypOtension
Pregnancy problems (fetal renal damage)
Rash
Increased renin
Lower angiotensin II
hyperkalemia