Cytokines, Cell surface proteins Flashcards Preview

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Flashcards in Cytokines, Cell surface proteins Deck (28):
1

Il-1 secreted by

macrophages

2

Il-1: 4 actions

acute inflammation
chemokine production to recruit leukocytes
activates endothelium to express adhesion molecules
endogenous pyrogen

3

Il-2 secreted by

Th1 cells

4

Il-2 action

Stimulates growth of helper and cytotoxic T cells

5

Il-3 secreted by

activated T cells

6

Il-3 action

Supports growth and differentiation of bone marrow stem cells

7

Il-4 secreted by

Th2 cells

8

Il-4 2 actions

Growth of B cells
Class switching to IgE and IgG

9

Il-5 secreted by

Th2 cells

10

Il-5 3 actions

Differentiation of B cells
Class switching to IgA
Production/activation of Eosinophils

11

Il-6 secreted by (2)

Th cells and macrophages

12

Il-6 2 actions

Production of acute-phase reactants
Production of immunoglobulins

13

Il-8 secreted by

macrophages

14

Il-8 action

Chemotaxis for neutrophils

15

Il-10 secreted by

regulatory T cells

16

Il-10 2 actions

inhibits activated T cells.
Activates Th2, inhibits Th1

17

Il-12 secreted by (2)

B cells and macrophages

18

IL-12 2 actions

Activates NK cells
Activates Th1 cells

19

gamma-interferon secreted by

Th1 cells

20

gamma-interferon 3 actions

stimulates macrophages
stimulates th1
inhibits th2

21

TNF secreted by

macrophages

22

TNF 2 actions

mediates septic shock
leukocyte recruitment

23

Th cells: 5 cell markers

CD4
TCR
CD3
CD28
CD40L

24

Tc cells: 3 cell markers

CD8
TCR
CD3

25

B cells: 7 cell markers

IgD
IgM
CD19
CD20
CD21
CD40
MHC II
B7

26

Macrophages: 7 markers

MHC II
B7
CD 14
CD 40
Fc receptor
C3b receptor
CD 16

27

NK cells: 3 markers

Receptors for MHC I
CD16
CD56

28

Markers found on all WBCs, RBCs, platelets (2)

CD55
CD59