Teratogens, torches Flashcards by Matt Seiffert

ACE inhibitors

renal damage

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Alcohol

FAS (birth defects, mental retardation)

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Alkylating agents (2)

Absence of digits

multiple anomalies

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Aminoglycosides

CN VIII toxicity

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Cocaine (3)

Abnormal fetal development
fetal addiction
placental abruption

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Diethylstilbestrol (DES)

Vaginal clear cell adenocarcinoma

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Folate antagonists

Neural tube defects

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Iodide (lack or excess) (2)

goiter

hypothyroidism

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Lithium

Ebstein’s anomaly (atrialized RV)

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Maternal diabetes

Caudal regression syndrome (anal atresia to sirenomelia)

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Smoking (4)

Preterm labor
Placental problems
IUGR
ADHD

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Tetracyclines

Discolored teeth

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Thalidomide

flipper limbs

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Valproate, carbamazepine

Inhibition of intestinal folate absorption: take 10x normal dose

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Warfarin (3)

Bone deformities
fetal hemorrhage
abortion

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X-rays, anticonvulsants

Multiple anomalies

Toxoplasma gondii: transmission

cat feces, undercooked meat

Toxoplasma gondii: mom

Asymptomatic, rarely lymphadenopathy

Toxoplasma gondii: neonate (3)

Chorioretinitis
Hydrocephalus
Intracranial calcifications

Rubella: transmission

respiratory droplets

Rubella: mom (3)

Rash
Lymphadenopathy
Arthritis

Rubella: neonate (3)

PDA (or pulm artery hypoplasia)
Cattaracts
Deafness (w/w/o blueberry muffin rash)

CMV: transmission

sex, organ transplants

CMV: mom

Usually asymptomatic, maybe mono-like

CMV: neonate (2)

``` Hearing loss (unilateral) Seizures ```

HIV: mom

Variable, depends on CD4 count

HIV: neonate (2)

Recurrent infections | Diarrhea

HSV: transmission

skin or mucous membrane contact

HSV: mom

Usually asymptomatic, maybe herpetic vesicular lesions

HSV: neonate (2)

Encephalitis | Herpetic (vesicular) lesion

Syphilis: mom (3)

Chancre Disseminated rash Cardiac/neurological disease

Syphilis: neonate (4)

stillbirth common hydrops fetalis facial abnormalities (notched teeth, saddle nose, short maxilla) saber shins