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Flashcards in Toxicities Deck (43):
1

Atropine-like CV effects (3)

TCAs
low potency neuroleptics
first generation antihistamines

2

Coronary vasospasm (2)

Cocaine
Sumatriptan

3

Cutaneous flushing (4)

Vancomycin
Adenosine
Niacin
Ca channel blockers

4

Dilated cardiomyopathy

Doxorubicin, daunorubicin

5

Torsades de pointes (9)

Class III (sotalol), class Ia (quinidine, antiarrhythmics
Cisapide
Macrolides
Haloperidol/risperidone
Chloroquine
Methaloquine
Methadone
Protease inhibitors

6

Agranulocytosis (6)

Clozapine
Carbamazepine
Colchicine
Propylthiouracil
Methimazole
Dapsone

7

Aplastic anemia (5)

Chloramphenicol
Benzene
NSAIDs
Propylthiouracil
Methimazole

8

Direct Coombs-positive hemolytic anemia

Methyldopa

9

Gray baby syndrome

Chloramphenicol

10

Hemolysis in G6PD deficient patients (6)

Isoniazid
Sulfonamides

Primaquine
Aspirin
Ibuprofen
Nitrofurantoin

11

Megaloblastic anemia (3)

Phenytoin
Methotrexate
Sulfa drugs

12

Thrombotic complicaitons

OCPs

13

Cough

ACE inhibitors

14

Pulmonary fibrosis (3)

BLeomycin
Amiodarone
Busulfan

15

Acute cholestatic hepatitis

Macrolides

16

Focal to massive hepatic necrosis (4)

Halothane
Valproic acid
Acetaminophen
Amanita phalloides

17

Hepatitis

INH

18

Pseudomembranous colitis (2)

Clindamycin
Ampicillin
(really, any antibiotic)

19

Adrenocortical insufficiency

Glucocorticoid withdrawal (HPA suppression)

20

Gynecomastia (7)

Spironolactone
Digitalis
Cimetidine
Alcohol
Ketaconazole
estrogens
marijuana

21

Hot flashes (2)

Tamoxifen
Clomiphene

22

Hypothyroidism (2)

Lithium
Amiodarone

23

Gingival hyperplasia

Phenytoin

24

Gout (2)

Furosemide
Thiazides

25

Osteoporosis (2)

Corticosteroids
Heparin

26

Photosensitivity (3)

Sulfonamides
Amiodarone
Tetracycline

27

Rash (Stevens-Johnson syndrome) (12)

Ethosuximide
Lamotrigine
Carbamazepine
Phenobarbital
Phenytoin
Sulfa drugs
Penicillin
Allopurinol
Penicillin
seizure meds
sulfa drugs

28

SLE-like syndrome (5)

Hydralazine
INH
Procainamide
Phenytoin
Sulfonamide

29

Tendonitis, tendon rupture, cartilage damage

Fluoroquinolones

30

Fanconi's syndrome (3)

Expired tetracycline
Heavy metals
Wilson's disease

31

Interstitial nephritis (3)

Methicillin
NSAIDs
Furosemide

32

Hemorrhagic cystitis (2)

Cyclophosphamide
Ifosfamide

33

Nephrotoxicity (2)

Cyclosporine
Tacrolimus

34

Cinchonism (dizziness, headache, tinnitus) (2)

Quinidine
Quinine

35

Diabetes insipidus (2)

Lithium
Demeclocycline
(treat with amiloride and hydrochlorothiazide)

36

Parkinson-like syndrome (5)

Haloperidol
Chlorpromazine
Reserpine
Metoclopramide
MPTP (illegal demorol)

37

Seizures (5)

Bupropion
Imipenem/cilastatin
Isoniazid
Evening primrose oil
Enfluorane

38

Tardive dyskinesia

Typical antipsychotics

39

Disulfiram-like reaction (5)

Metronidazole
Cephalosporins
Procarbazine
First generation sulfonylureas
Disulfyram

40

Nephrotoxicity/Neurotoxicity

Polymyxins

41

Nephrotoxicity/ototoxicity (4)

Aminoglycosides
Vancomycin
Loop diuretics
Cisplatin

42

P-450 Inducers (8)

Quinidine (Queen)
Barbiturates (Barb)
St. John's wort (Steals)
Phenytoin (Phen-phen)
Rifampin (and refuses)
Griseofulvin (greasy)
Carbamazepine (carbs)
Chronic alcohol use (chronically)

43

P-450 inhibitors (8)

Sulfonamides
Isoniazid
Cimetidine
Ketoconazole
Erythromycin
Grapefruit juice
Acute alcohol use
Protease inhibitors