Immunosuppressants Flashcards Preview

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Flashcards in Immunosuppressants Deck (10):
1

Precursor of 6-mercaptopurine

Azathioprene

2

May prevent nephrotoxicity with mannitol diuresis

cyclosporine

3

Antibody that binds to CD3 on T cells

murominab

4

Antibody that binds to IL-2 receptor on activated T cells

daclizumab

5

Inhibits inosine monophosphate dehydrogenase

mycophenylate

6

Inhibits calcineurin, leading to loss of IL-2 production, leading to blockage of T cell differentiation and activation

cyclosporine

7

binds FK-binding protein, leads to loss of IL-2 production

tacrolimus

8

binds FKBP-12, leads to inhibition of mTOR, leads to inhibition of T cell proliferation

cerolimus

9

used for lupus nephritis

mycophenylate

10

Metabolized by xanthine oxidase, therefore allopurinol increases its toxicity

azathioprene