Cancer Drugs: the cover-your-ass, bare bones version

Question 1

Mechanism for etoposide

Answer 1

Forms complex between topoisomerase II and DNA

Question 2

Mechanism for busulfan

Answer 2

alkylates DNA

Question 3

Toxicity for busulfan

Answer 3

pulmonary fibrosis

Question 4

Mechanism for bleomycin

Answer 4

fragments DNA

Question 5

Toxicity for bleomycin

Answer 5

pulmonary fibrosis

Question 6

Mechanism for 6-mercaptopurine

Answer 6

blocks purine synthesis

Question 7

Metabolism of 6-mercaptopurine is accomplished by:

Answer 7

xanthine oxidase

Question 8

Mechanism for cisplatin and carboplatin

Answer 8

cross-links DNA

Question 9

Toxicity for cisplatin, carboplatin (2)

Answer 9

nephrotoxic, ototoxic

Question 10

Mechanism for cyclophosphamide

Answer 10

Nitrogen mustard, alkylates DNA (electrophile that binds DNA)

Question 11

Mechanism for methotrexate

Answer 11

Folic acid analog, inhibits dihydrofolate reductase

Question 12

Mechanism for paclutaxol

Answer 12

Prevents tubulin disassembly

Question 13

Mechanism for doxyrubicin and danirubicin

Answer 13

Intercalates DNA, produces oxygen free radicals

Question 14

Toxicity for doxyrubicin and danirubicin

Answer 14

cardiotoxic

Question 15

Mechanism for nitrosureas

Answer 15

DNA alkylating agents, used in brain cancer

Question 16

Mechanism for vincristine and vinblastine

Answer 16

Prevents tubulin assembly

Question 17

Mechanism for 5-fluorouracil

Answer 17

Inhibits thymidylate synthase, leads to decreased nucleotide synthesis

Question 18

Mechanism for tomaxafen/rumoxifen

Answer 18

SERM: blocks estrogen binding to ER+ cells

Question 19

Mechanism for cytaravine (similar to…)

Answer 19

Inhibition of DNA polymerase: similar to acyclovir and foscarnet

Question 20

Mechanism for etoposide (similar to…)

Answer 20

Inhibition of topoisomerase II: similar to fluoroquinolones

Question 21

Mechanism for methotrexate (similar to…)

Answer 21

Folic acid analog, inhibits dihydrofolate reductase: similar to trimethoprim

Question 22

Mechanism for trastuzimab

Answer 22

Monoclonal antibody against HER-2

Question 23

Mechanism for bleomycin, oxyrubicin, danirubicin

Answer 23

Free radical induced DNA strand breakage

Question 24

Mechanism of 6-mercaptopurine

Answer 24

Inhibitor of PRPP synthetase

Question 25

Methotrexate: reversible by...

Answer 25

Leucovorin

Question 26

3 treatments for choriocarcinoma

Answer 26

methotrexate, vincristine, vinblastine

Question 27

Treatment for AML

Answer 27

cytarabine

Question 28

2 treatments for CML

Answer 28

Busulfan, amatanib

Question 29

Prevents breast cancer (2)

Answer 29

Tamoxifen, raloxifene

Question 30

3 treatments for testicular cancer

Answer 30

etoposide, bleomycin, cisplatin

Question 31

Topical treatment for AKs and basal cell cancers

Answer 31

5-fluorouracil

Question 32

Dactinomycin: use

Answer 32

childhood tumors (Ewing's sarcoma, Wilm's tumor, rhabdomyosarcoma)

Question 33

Mechanism of hydroxyurea

Answer 33

Inhibits ribonucleotide reductase

Question 34

Drug with side effect of hemorrhagic cystitis

Answer 34

cyclophosphamide

Question 35

Mechanism for imatinib

Answer 35

Antibody against Philadelphia chromosome

Question 36

Know 9 side effects of Prednisone

Answer 36

``` Cushing-like symptoms Immunosuppression Cataracts Acne Osteoporosis Hypertension Peptic ulcers hyperglycemia Psychosis ```