Blocks 19-28 Flashcards
(227 cards)
What potentially damaging enzyme is made by alveolar macrophages?
Alveolar macrophages make elastase, which can be damaging if it is allowed to run out of control.
How do you minimize confounding in an experiment?
Confounding is minimized in an experiment by controlling for as many variables as possible.
What is the similarity between myasthenia gravis and goodpasture’s syndrome?
Both goodpasture’s syndrome and myasthenia gravis are type 2 autoimmunities
What does lysosomal enzyme release by macrophages lead to in the lung?
Lysosomal enzyme release by macrophages in the lung leads to lung destruction and abscess formation.
The release of what enzyme is stimulated by an increase in free fatty acids?
Insulin release is stimulated by an increase in free fatty acids. These also prevent the potentially beneficial effects of insulin.
What enzyme is released by osteoblasts to allow for calcium deposition in osteoid?
Osteoblasts release alkaline phosphatase to increase the pH in the osteoid to allow for calcium deposition.
Where is the CTZ located?
The CTZ is located in the dorsal inferior medulla
How does eplerenone work?
Eplerenone is an antialdosterone agent used in the management of CHF. It is a potassium sparing diuretic.
What is the natural history of hemangiomas?
Hemangiomas will initially grow with the child after birth, but will almost always regress before puberty.
What is the best therapy for the management of an acute manic attack?
Valproate is the best choice for the management of an acute manic attack.
What is the order of steps for repairing DNA damage caused by cytosine deamination and cross-linking?
The order of steps leading to DNA repair is: glycosylation, endonuclease , lyase, DNA polymerase, and ligase.
Which enzymes activate and inhibit 6-MP respectively?
HGPRT activates 6-MP and Xanthine oxidase inhibits it.
How thiazolidinediones work?
Glitazones work by modifying transcription of glucose and lipid metabolizers
How does calcium play a role in muscle fiber activation?
Calcium binds troponin in the muscle fiber to initiate movement.
What does an obstructive lesion in a bronchus lead to?
An obstructive lesion in a bronchus leads to collapse of the lung tissue and deviation of the trachea to the side of the collapse
How do eosinophils work?
Eosinophils work by initiating ADCC.
How can amphotericin cause PVCs?
Amphotericin can cause renal damage leading to PVCs.
How is the murmur of aortic stenosis defined?
Aortic stenosis has a characteristic crescendo-decrescendo murmur
How does rabies get into the brain?
Rabies climbs up the peripheral nerve to the junction with the CNS axon. It can then cross the synapse and bind acetylcholine receptors on the far side allowing it to get into the CNS
What is one condition that can cause hypoxemia in the lower extremities, but not in the upper?
PDA can cause hypoxemia in the lower extremities, but not in the upper. Go for this over coarctation unless you have a good reason.
What is the system that leads excess dopamine to cause galactorrhea?
The tuberoinfundibular system is responsible for excess dopamine causing galactorrhea.
What are the two go to agents for managing VTAC?
Lidocaine or amiodarone are the go-to agents with the highest specificity for cardiac tissue in the management of VTAC
What is the relationship between oxygen content and blood flow in the lung?
Unlike in other systems blood is shunted away from areas in the lung with low oxygen content.
What is the most common cause of congenital adrenal hyperplasia? What is blocked by this mutation?
21 hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia. It prevents the conversion of progesterone to 11-deoxycortisone.