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RUSVM Bacteriology Gram Negatives > Borrelia > Flashcards

Flashcards in Borrelia Deck (33):
1

Borrelia Gram___? Shape?

Gram Negative- stain poorly

Classic spirochetes

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2

Borrelia Name the 3 animal pathogen species

B. anserina

B. theileri

B. burgdorferi sensu lato

3

What disease does Borrelia anserina affect

Fowl Spirochetosis

4

What pathogen causes Fowl Spirochetosis?

Borrelia anserina

5

What species does Borrelia theileri affect

Cattle (Occasionally sheep & horses)

6

What disease does Borrelia sensu lato cause?

Lyme Disease!!!

7

What species does Borrelia sensu lato affect?

Lyme Disease, 3 genospecies

Dogs - Humans - Horses  (few others)

8

Describe Borrelia chromosomes

Linear, double-stranded

Multiple linear & cirucular plasmids

9

What aspects cause Borrelia to need specialized media for culture?

-Slow-growing -Microaerophilic -Ferment glucose

10

Borrelia Reservoir

Tick vectors! -Transmit bacteria during feeding, through bite wound

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11

Borrelia Transmission

-Tick vectors

-Short-term, other arthropods

-Placental - Milk - Urine

12

What animals suffer from Fowl Spirochetosis?

Mainly Chickens!

-Turkeys - Geese - Ducks - Pheasants - Pigeons - Canaries - other wild birds

13

What are the clinical signs of Fowl Spirochetosis

B. anserina

-Fever - Depression - Anorexia - Cyanosis - Green Diarrhea - Paralysis - Anemia - Hepato/splenomegaly - Hemorrhage

14

What is the mortality rate of Fowl Spirochetosis (B. anserina)

10-100%

increased in younger birds

15

Borrelia anserina Distribution

Fowl Spirochetosis

Worldwide distribution

Not common in US

16

What species of tick is the main vector and reservoir?

Soft tick (Argas persicus)

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17

Describe the appearance of the liver, as a result of B. anserina (Fowl Spirochetosis)

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Liver often enlarged, mottled, with necroses of various size & marginal infarctions

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18

B. anserina (Fowl Spirochetosis) Treatment

Antimicrobials (Penicillin, tetracycline, chloramphenicol ...etc)

-Immune Serum

- Bacterin vaccines

- Control the parasites!!

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19

Borrelia theileri Distribution

Cattle -Africa & Australia

20

What does Borrelia theileri cause in cattle?

Mild febrile anemia

21

What is the treatment for Borrelia theileri?

Tetracycline works if needed (unclear pathogenesis)

-Control the Parasites! 

22

Lyme Borreliosis What species of Borrelia cause this?

B. burgdorferi sensu lato:

-B. burgdorferi sensu stricto

-B. garinii

-B. afazelii

23

What months are Lyme Borreliosis most prevalent?

May - October

24

What species of ticks spread Lyme Borreliosis

-Ixodes scapularis -Ixodes pacificus (Sylvatic cycle- Deer)

25

Lyme Borreliosis in humans

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-Most infections subclinical

-Begins with skin lesion (Erythema migrans)

-Eventually neural, cardiac, and arthritic complaints (weeks-months later)

26

Lyme Borreliosis Pathogenesis in humans

-Endotoxin

-Hemolysin

-Immune complexes

-Immunosuppression

27

Lyme Borreliosis Clinical signs in Dogs

-Polyarthritis* -Fever* -Anorexia*

-Malaise

-Lymphadenopathy

-Carditis

-Renal Disease

28

Lyme Borreliosis In cats

Uncommon!

29

Lyme Borreliosis Clinical signs in Horses

-Polyarthritis

-Ocular & neural involvement

-Foal mortality

30

Lyme Borreliosis Clinical signs in cattle

Similar to horses:

-Polyarthritis

-Ocular & neural involvement

-Calf mortality

31

Lyme Borreliosis Diagnosis

-Culture is difficult

-Dark-field microscopy

-Serology (ELISA, IFA, Western) (Antibody titers)

-Molecular (PCR)

32

Lyme Borreliosis Treatment

**Doxycycline**

-Tetracycline, enrofloxacin, erythromycin, peniccilin

**TICK CONTROL***

33

Lyme Borreliosis Immunological Factors/Prevention

Humoral = essential for protection

- Vaccines available

(Bacterin, OspA against B. burgdorferi in tick gut)