Salmonella Flashcards Preview

RUSVM Bacteriology Gram Negatives > Salmonella > Flashcards

Flashcards in Salmonella Deck (25):
1

Salmonella description

*Motile*, Most are Lactose fermenters, *produce H2S*, gram negative, small rods

2

Salmonella 2 species

S. bongori (many serovars) & S. enterica (many subspecies)

3

Salmonella - Antigenic composition

O antigen (LPS) and H antigen (flagella)

4

Salmonella adhesins

Fimbria/pili - attach M cells - Pef, Agf or curli and long polar fimbra Lpf

5

Salmonella Pathogenicity islands

Effector proteins mediate uptake, *ruffle formation*, intra-macrophage survival, death of activated macrophages, unknown functions

6

Salmonella Pathogenicity island types

Secreted proteins - Outer proteins- system effectors - system apparatus - Magnesium transport

7

Salmonella reservoir

GI tract of animals, ubiquitous geographically & zoologically - Normal flora prevent disease

8

Salmonella pathogenesis

Adherence to M cell/Epithelial cell--> injection of effectors & internalization--> replication & cell death --> chemokine release (inflammation--> hemorrhagic diarrhea) --> dissemination maybe, septicemia

9

Salmonella in ruminants

Feedlots! Young & adults - Intestinal & deptic presentation (pneumonia & abortion, osteomyelitis/Joint ill)

10

Salmonella species in cattle

S. dublin (pneumonia in calves), S. typhimurium, S. newport

11

Salmonella species in sheep

S. typhimurium, S. abortus ovi

12

Salmonella in Swine

**Hog Cholera bacillus** DDx=classical swine fever

13

When I say hog cholera, you say...

Salmonella!

14

Salmonella in horses

Common in adults, diarrhea - GI tract surgeries/colic/antimicrobial tx predisposes them

15

Salmonella in dogs/cats

Carriers - outbreaks from contaminated food or treats

16

Salmonella in poultry! 4 main diseases

Paratyphoid - Pullorum - Fowl typhoid - Avian arizonosis

17

Salmonella - Paratyphoid disease

S. enteridis & typhimurium - High losses first 2 wks old - Survivors=asymptomatic shedders - Ingestion/fecal contamination - Button type lesions on small intestine

18

If you see button-type lesions on SI, you say...

Paratyphoid disease! S. enteridis & typhimurium

19

Pullorum diseases

Non-motile Pullorum - Bacillary white diarrhea - Grey nodules in heart, lung, liver

20

When you see white diarrhea and grey nodules in heart, lung, liver, you think...

Pullorum diseases! Salmonella

21

Fowl Typhoid

S. gallinarum - Similar to pullorum but in adults too - REPORTABLE in USA

22

Salmonella in humans

Foodborne zoonoses - infection depends on dose, serotype, immune status - Typhoid Fever from Typhoid Mary - Gastroenteritis - Septicemia

23

Typhoid fever in humans, you say...

Salmonella infection!

24

Salmonella Immunity

Normal flora compete - Opsonins & anti-adhesins - Activated macrophages/PMN/ NKCs - Vaccinaiton (challenging)

25

Salmonella Selective media

Lactose fermentors! Produce H2S! So: MacConkey agar, Brilliant Green agar, Xylose Lysine agar, HE agar, Eosin methylene blue, TSI ----etc