Breast Dx+neoplastic breast Flashcards Preview

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Flashcards in Breast Dx+neoplastic breast Deck (28):
1

medullary carcinoma micrscopy

syncytial growth pattern

high nuclear grade

lymphoplasmacytic infiltrate

pushing, nonifiltrative border 

ugly cells oftenin sheets 

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1

colloid (mucinous) carcinoma presetation

postmenopausal

slow growing

axillary metastases

slightly higher in BRCA1

2

most common regions for carcinoma

upper outer

sub areolar

2

4 molecular subtypes of carcinoma of breast

Laminal A

Luminal B (poorer prognosis)

HER2 psotive

Basal like (triple negative)

3

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comedo carcinoma in situ

4

tubular carcinoma microscopic findings

single later of eptihelail cells linging glands

no myoepithelail layer

glands scattered in desmoplastic stroma

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5

gynecomastia morpholgy

subareolar mass possible

periductal hyaline, collagenous tissue

epithelial hyperplasia of ducts

6

ductal carcnimoma in situ histopathoogical types

Comdeo

Non-comedo 

(cribrifomr, micropapillary, papillary, solid, flat/clinging)

7

most important prognostic factor for invasive carcinoma in absence of distant metastases

axillary node status

8

Oncotype=

applicable for pt with early carcinoma, small, node negaative, ER+

expression of a set of genes predictsresponse to chemo

9

invasive lobular carcinoma microscopic features

small cells

single file pattern or targettoid pattern

no glands

intracytoplasmic mucin vacuoes

signet ring cells

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10

invasive lobular carcinoma presentation

metastasis pattern

often postmenopause, 

multicentric

often contralateral carcinoma (previous or lateer)

metatases: CSF, serosal surfaces, GI, Ovary, uterus, bone marrow

11

inflammatory carcinoma presentation 

erythema

peau d'orange

induration of parenchyma

thickening of skin

lymphatic tumor emboli 

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13

non-comedo varieties of DCIS

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cribriform

solid

papillary

micropapillary

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14

medulalary carcinoma mutation

increased with BRCA1

does not overexpress Her2/Neu,

negative for ER/PR

15

colloid mucinous carcinoma mamogram, gross, microscopy

well circumscribed and lobulated

soft, pale blue gelatinous surface

cells nested in pools of mucin

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16

male breast carcinoma presentation

 

discharge

axillary lymph imvolvement at presentation in half of cases

distant metatases  > lungs, brain, bone ,liver

prognosis and treatment the same as in women

17

gynecomastia seen in 

Klinefelter XXY 

Cirrhosis

Alchol, marjuana, anabolics

functionign testicular tumor

19

most common histologic types of breast CA

ductal carcinoma in situ

lobular carcinoma in situ

invasive carcinoma - non specified

20

risk factors male breast carcinoma

1at degree relative

decreased teseticualr fucntion

epxposure to exogenous estrogens

increasing age, infertility, obesity

BRCA2 mutation

21

prognostic lab markers

estrogen receptor

progesterone receptor

HER2Neu FISH/IHC

22

tubular caarcinoma mammogram, gross, presentation

40s

multifocal, peripheral breast

mam: small stellate lesion in asymptomatic woman

gray, white, firm 

23

medullary carcinoma mammogram and gross

mam: oval circumscribed mass

often mistaken for fibroadenoma

gors: soft, fleshy, lobulated bulging cut surface

24

pagets disease of the ipple = 

 

presentation and histo

DCIS extending to nipple and areola

ulcerated exzematous skin

carcinoma cells in epidermis

usually high grade or comedo type 

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25

mammography and gross features invasive lobulaar carcinoma

mam often negative, asymmetric, ill defined

spiculated mass/density

gross: hard, irregular bordders

blends to surrounding tissue

26

invasive ductal carcinoma histo and associations

mutations

majority of carcinomas

range of features

firm, white masses with distinct borders

usually with DCIS

2/3 ER/PR, 1/3 overexpress Her2/Neu

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27

invasive ccarcinoma presentation and mammogram 

paloable mass

dimpling

retraction of bipple

mass , density or caclifications on imaging 

28

Lobular carcinoma in situ presentatoin

44-54

often multicentric, bilarteral

rare calcifications

no density/mass

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