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Flashcards in Abnormal bleeding Deck (11):
1

mechanism of hormonally responsivity of uterine fibroids

increased amts of estrogen and progesterone mRNA

1

anovulation with abnormal uterine bleeding results from

 chronic exposure of endometrium to estrogen without beefit of cyclic exposure ot postovulatory progesterone

endometrium becomes abnromally thickened and structurally incompetent

2

endometriosis = 

presence of endometrial glnads and stroma outside the endometrial cavity and uterine musculature

can result in ahesions, pain, infertility and inflammation

4

time of appearance uterine fibroids

reproductive years

rare before puberty

typically regress before menopause

5

menometrorrhagia = 

oligomenorrhea =

metorrhagia =

menorrhagia = 

menometrorrhagia = irregualr bleeding intervals with ecessive flow or duration

oligomenorrhea =mensturation fewer than 9 times per year (>35 day interval)

metorrhagia =irregular intervals

menorrhagia = excessive bleeding (>7d, >80mls)

6

overall risk of progression to endometrial cancer based on

duration of unopposed estrogen exposure

7

endometriosis contributes to infertility via

ahesions distort anatomy

ovarian cysts

macrophages and cytokines .> inflammatory state

adversely affects endometrial receptivity

8

increases risk of uterine fibroids

decreases risk

parity decreases risk

obesity increases risk

9

benign uterine neoplasms

endometrial polyps - fleshy outgrowths

 

endocervical polyps - outgrowths of cervical mucosa

 

adenomyosis - invasion of endometrium into myometrium, causes menorrhagia and dysmenorrhea, enlarged, tender uterus

10

endometrial atrophy = 

often described as spotting

related to hypoestroenism

clinically similar to endometrial cancer: Biopsy!!

11

symptoms leiomymoma (uterine fibroids) 

menorrhaiga, menometrorrhagia

refractory anemia

spotting

pelvic pain

mass symptoms (urinary pressure/urgency, flank pain, abd girth)