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Flashcards in GU infxn Deck (34):
1

treatment herpes 

famciclovir nucleoside anlogs 

(processed by viral but not host DNA polymerase leading to chain termination)

2

congenital syphyllis does not damage fetus until ____

4th month (Abx can prevent)

3

treatment mollucscum contagiosum

scraping, liquid N, iodine

ritonavoir or cidofovir in immunocompromised patients with dleayed clearance

4

viral mophology mollucum contagiosum (pox virus)

ovoid to brick shaped

linear doubled standed DNA

rep;icate exlcuisvely in cytoplasm (carries all necessary proteins)

transmits via direct contact

5

treatment Chlamydia trachomatis

single dose IM ceftriaxone (to taget N gonorrhoeae)

7d course oral doxycycline or 1 oral dose azithromycin

6

presentation, dx and treatment candida albincans

vaginal itching and thick copious discarhge

increased incidence in antibiotic, new OBC, menses, pregnancy

 

dx via KOH prep

treatment Imidazole suppositories or single dose fluconazole

7

morphology gardnerella vaginalis

pleomorphic gram neg rods

not dependent on X factor or V factor for growth (as the simular haemophilus ducreyi is)

7

Jarisch Herxheimer Phenom

worsening of symptoms of T pallidum infxn after starting ABx due to pyrogen release by killed organism

7

Chalmydia tachomatis mrophology

 

cell target

gram negative

oblligate intracellular

ATP/ADP ranslocator usurbs host energy 

tiny, not easily seen on gram stain 

targets columnar epithelia cells at mucous membranes

8

presentation and diagnosis molluscum contagiosum

nodular wart like lesions

begin as papules and become ubillicated with central caseous plug

clusters of 5-20 nodules

Dx based on lesions and histology of large eosinopihllic cystoplasmic inclusions (mollluscum bodies)

9

Dx treponema pallidum

VDRL and RPR - abs against cardiolipin and lecithin release during bacterial damage (non-specific)

FTA-ABS - IFA to detect abs agasint T pallidum

PCR

10

Tertiary treponema palllidum:
Gummatous syphyllis =

cardiovascualr syphillis:=

neurosyphillis =

Gummatous syphyllis = - localied granulamouts lesions in skin/bones, noninfectious

cardiovascualr syphillis:= aneurysm in ascending aorta or arch, due to destruction of small arterioles supplying aorta

neurosyphillis = asymptomatic, subactue with fever, stiff neck, headache. Meningovascular with infarction due to ceerebral vessel damage. Tabes dorsales if spinal cord affected

10

presentation and dx, trichomonas vaginallis

most males asymptomatic, urethrtitis, prostatitis rare

scant watery discharge in females, posssible vaginitis+ painful urination

 

Dx via microscopy

11

dx chlamydia trachomatis

by elcusion

cytoplasmic inlcusions on giemsa stain or scarpings

PCR for DNA can be obtained from urine 

12

presentation and dx garnerella vaginallis

part of normal flor

vaginitis, 

prurititis, dysuria

prulent discharge with fishy ordor

 

dx with clue cells (multple pleomorphic bacterira in discharge)
Whiff test - amine odor when KOH added to sample

high PH

13

presentation and diagnosis haemophilus ducreyi

chancroid - tender papule with ertyhtmatous base

progresses to painful ulceration with assocd. LAD (unilateral)

 

dx based on culture, PCR of ulcer of lymph node aspiarates

13

ureaplasma urealyticum morphology

mycoplasma family - no cell wells, (beta lactams and gram stain don't work)

pleomorphic shape

urease breaks down urine into amonia > alakaline urine

14

disease presentations Chlamydia trachomatis (5)

Non gonococcal urethritis - most commom STI, dysuria, mucoid discharge
PID - abnl vaginal discahrge, bloeeding, intense lower Adb pain
chlamydial epididymitis - unilateral scotal swelling, tenderness, pain
lymphogranuloma venereum - painless papule > heals. invades unilateral inguinal lymph nodes > drainprulent exudate through sinus tracks
Reiter's syndrome- complication - arthritis, conjuncitivits, blanitis circinata, keratodermia blenorrhagia (scaly rash on palms and soles)

15

Neisseria gonorrhea morphology

Gram neg dipplococci

oxidase positive

pili, outer membran porins (for invasion to epithelal)

opa proteins

iga proteast

LPS mediated destruction of cilia on neighboring cells

17

treatment Ureaplasma urealyticum

erthromycin 

tetracycline

18

dx + presentation herpes simplex

HSV 1 or 2 specific antibodies 

fevere 

headaces 

malaise

myalgias

LAD

19

Diease presentation neisseria gonorrheae

 

dx

urethritis with painful urination 

purulent discharge

epididiymiiis, prostatitis, urethral strictures

endocervictis, PID

bacteriemia +septic arthritis > extremity lesions, fever

 

dx via gram stain on Thayer Marter VCM

21

presentation adn ddx ureaplasma urealyticum

carried by 60% healthy women

due to infection of  lower UT 

dyruria, yellow mucoid discharge

 

dx via pCR or culture (requires cholesterol and urea for growth)

tiny colonies (T-strain)

22

treatment hameophilus ducreyi

azithromycin

ceftriaxone, 

ciprofloxacin

23

morpohlogy treponem a pallidum

gram negative spirochete

extra out membrane

perplasmic flagella

24

treatment gardernella vaginallis

metronidazole (flagyl)

clindamycin)

26

haemophilus decryi morphology

coccobacilli

facultative aneraobes

often associated with mucous membranes

27

trichomonas vaginallis morphology

four flagella, undulating membrane

trophozoite only form

28

treatment trichomonas vaginalis

metronidazole (flagyl)

 

tinidazole if resistant

30

pathophys of PHV integration events

disrupt expression of viral E2 gene - negative regulato of viral e6 and 37 oncogenes

31

HPV morphology and significant strains

papovirus, small circular DS DNA, 

icosahedral, capsid, not eveloped

most genital caused by HPV 6 and 11

high risk 16 18 31 46

32

treatment T pallidum

penicillin 

ethrythromycin

doxycycline

33

treatment Neisseria gonorrheae

IM ceftriaxone

(erthromycin eye drops prophylatic at birth)

34

infection stages treponema pallidum

primary - chancre, highly infectious, painless

secondary - hematogenic sprea, rash, feve LAD,alopecia, highy contagious condyloma latum   at moist sites

;atent - asymptomatic, noninfectious (except fetal)

tertiary - slow inflammaition driven damage to organs