GU infxn Flashcards

(34 cards)

1
Q

treatment herpes

A

famciclovir nucleoside anlogs

(processed by viral but not host DNA polymerase leading to chain termination)

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2
Q

congenital syphyllis does not damage fetus until ____

A

4th month (Abx can prevent)

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3
Q

treatment mollucscum contagiosum

A

scraping, liquid N, iodine

ritonavoir or cidofovir in immunocompromised patients with dleayed clearance

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4
Q

viral mophology mollucum contagiosum (pox virus)

A

ovoid to brick shaped

linear doubled standed DNA

rep;icate exlcuisvely in cytoplasm (carries all necessary proteins)

transmits via direct contact

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5
Q

treatment Chlamydia trachomatis

A

single dose IM ceftriaxone (to taget N gonorrhoeae)

7d course oral doxycycline or 1 oral dose azithromycin

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6
Q

presentation, dx and treatment candida albincans

A

vaginal itching and thick copious discarhge

increased incidence in antibiotic, new OBC, menses, pregnancy

dx via KOH prep

treatment Imidazole suppositories or single dose fluconazole

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7
Q

morphology gardnerella vaginalis

A

pleomorphic gram neg rods

not dependent on X factor or V factor for growth (as the simular haemophilus ducreyi is)

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7
Q

Jarisch Herxheimer Phenom

A

worsening of symptoms of T pallidum infxn after starting ABx due to pyrogen release by killed organism

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7
Q

Chalmydia tachomatis mrophology

cell target

A

gram negative

oblligate intracellular

ATP/ADP ranslocator usurbs host energy

tiny, not easily seen on gram stain

targets columnar epithelia cells at mucous membranes

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8
Q

presentation and diagnosis molluscum contagiosum

A

nodular wart like lesions

begin as papules and become ubillicated with central caseous plug

clusters of 5-20 nodules

Dx based on lesions and histology of large eosinopihllic cystoplasmic inclusions (mollluscum bodies)

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9
Q

Dx treponema pallidum

A

VDRL and RPR - abs against cardiolipin and lecithin release during bacterial damage (non-specific)

FTA-ABS - IFA to detect abs agasint T pallidum

PCR

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10
Q

Tertiary treponema palllidum:
Gummatous syphyllis =

cardiovascualr syphillis:=

neurosyphillis =

A

Gummatous syphyllis = - localied granulamouts lesions in skin/bones, noninfectious

cardiovascualr syphillis:= aneurysm in ascending aorta or arch, due to destruction of small arterioles supplying aorta

neurosyphillis = asymptomatic, subactue with fever, stiff neck, headache. Meningovascular with infarction due to ceerebral vessel damage. Tabes dorsales if spinal cord affected

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10
Q

presentation and dx, trichomonas vaginallis

A

most males asymptomatic, urethrtitis, prostatitis rare

scant watery discharge in females, posssible vaginitis+ painful urination

Dx via microscopy

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11
Q

dx chlamydia trachomatis

A

by elcusion

cytoplasmic inlcusions on giemsa stain or scarpings

PCR for DNA can be obtained from urine

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12
Q

presentation and dx garnerella vaginallis

A

part of normal flor

vaginitis,

prurititis, dysuria

prulent discharge with fishy ordor

dx with clue cells (multple pleomorphic bacterira in discharge)
Whiff test - amine odor when KOH added to sample

high PH

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13
Q

presentation and diagnosis haemophilus ducreyi

A

chancroid - tender papule with ertyhtmatous base

progresses to painful ulceration with assocd. LAD (unilateral)

dx based on culture, PCR of ulcer of lymph node aspiarates

13
Q

ureaplasma urealyticum morphology

A

mycoplasma family - no cell wells, (beta lactams and gram stain don’t work)

pleomorphic shape

urease breaks down urine into amonia > alakaline urine

14
Q

disease presentations Chlamydia trachomatis (5)

A
  • *Non gonococcal urethritis** - most commom STI, dysuria, mucoid discharge
  • *PID** - abnl vaginal discahrge, bloeeding, intense lower Adb pain
  • *chlamydial epididymitis** - unilateral scotal swelling, tenderness, pain
  • *lymphogranuloma venereum** - painless papule > heals. invades unilateral inguinal lymph nodes > drainprulent exudate through sinus tracks
  • *Reiter’s syndrome-** complication - arthritis, conjuncitivits, blanitis circinata, keratodermia blenorrhagia (scaly rash on palms and soles)
15
Q

Neisseria gonorrhea morphology

A

Gram neg dipplococci

oxidase positive

pili, outer membran porins (for invasion to epithelal)

opa proteins

iga proteast

LPS mediated destruction of cilia on neighboring cells

17
Q

treatment Ureaplasma urealyticum

A

erthromycin

tetracycline

18
Q

dx + presentation herpes simplex

A

HSV 1 or 2 specific antibodies

fevere

headaces

malaise

myalgias

LAD

19
Q

Diease presentation neisseria gonorrheae

dx

A

urethritis with painful urination

purulent discharge

epididiymiiis, prostatitis, urethral strictures

endocervictis, PID

bacteriemia +septic arthritis > extremity lesions, fever

dx via gram stain on Thayer Marter VCM

21
Q

presentation adn ddx ureaplasma urealyticum

A

carried by 60% healthy women

due to infection of lower UT

dyruria, yellow mucoid discharge

dx via pCR or culture (requires cholesterol and urea for growth)

tiny colonies (T-strain)

22
Q

treatment hameophilus ducreyi

A

azithromycin

ceftriaxone,

ciprofloxacin

23
morpohlogy treponem a pallidum
gram negative spirochete extra out membrane perplasmic flagella
24
treatment gardernella vaginallis
metronidazole (flagyl) clindamycin)
26
haemophilus decryi morphology
coccobacilli facultative aneraobes often associated with mucous membranes
27
trichomonas vaginallis morphology
four flagella, undulating membrane trophozoite only form
28
treatment trichomonas vaginalis
metronidazole (flagyl) tinidazole if resistant
30
pathophys of PHV integration events
disrupt expression of viral E2 gene - negative regulato of viral e6 and 37 oncogenes
31
HPV morphology and significant strains
papovirus, small circular DS DNA, icosahedral, capsid, not eveloped most genital caused by HPV 6 and 11 high risk 16 18 31 46
32
treatment T pallidum
penicillin ethrythromycin doxycycline
33
treatment Neisseria gonorrheae
IM ceftriaxone (erthromycin eye drops prophylatic at birth)
34
infection stages treponema pallidum
primary - chancre, highly infectious, painless secondary - hematogenic sprea, rash, feve LAD,alopecia, highy contagious *condyloma latum * at moist sites ;atent - asymptomatic, noninfectious (except fetal) tertiary - slow inflammaition driven damage to organs