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Flashcards in Male repro pharm Deck (22):
1

GnRH analog that inhibits testosterone secretion

Leuprolide

1

PGE1  analog

 

PDE5 inhibitors

PGE1 - Alprostadil 

 

PDE5 - sildenafil

vardenafil

tadafil

2

17-alplha alkylated testosterone, impedes hepatic catabolism

stanozolol

2

mechanism stanozolol

 

side effect

17-akpha alkylated testosterone, retards hepatic catabolism

 

hepatotoxicity

4

external/internal genitalia

hair follicles,

erythropoiesis 

regulated at

 

androgen receptor

4

PDE5 inhibitors mechanism

 

side effects + duration

PDE5 inhibitors - enhances concentration of cGMP (formation stimulated by NO) by inhibiting breakdown

 

Sildenafil (5h)- headache, flushing, bluish vision (PDE6)
Tadalfil (36h) - headache, dyspepsia, back pain
Vardenafil - headache, flushing

6

catalyzes Testosterone to DHT

5 alpha reductase

7

mechanisn, flutamide

 

indications

 

side effects

nonsteroidal competitive inhibitor of androgen receptor

 

metastatic prostate cancer, hirsutism in women

 

hepatic failure side effect

7

mechanism, Alprostadil

 

indications

 

side effects

PgE1 analog

 

injection or supository for ED

 

penile pain, urethral burning

9

other uses of androgens

muscle wasting in AIDS

blood dyscrasias - adjunct in anemia, TTP

angio edema (stanozolol) stimulate hepatic release of C1-esterase inhibitor

endometriosis and fibrocystic breast disease

anabolic steroids 

10

finasteride mechanism

 

indications

 

side effect

5 alpha reductase antagonist,
reduces T > DHT, especially in external genitalia

 

BPH, male pattern baldness

 

impotence, decreased libido

11

non-steroidal, competitive inhibitor of androgen receptor

flutamide

11

PDE5 inhibitors 

Sildenafil

vardenafil

tadalafil

13

mechanism leuprolide

 

indications

GnRH analog 

inhibits LH secretion > stimulation of gonadotropin > 

> leads to down regulation of GnRH reeeptor > inhibits gonadotropin secretion, > inhibits T secretion

 

advanced prostate cancer, endometriosis, central precocious puberty

14

adverse effects of androgen ause

1. decreased sperm production, testicular atrophy, sterility

2, high doses > erythrocytosis

3. Gynecomastia

4.  17-alkylated T decrease HDL, increase LDL

5. stunting of linear growth

15

androgen receptor antagonists have limited efficacy becasue

 

work-around  =

increase LH secretion 

 

admin with GnRH analog

16

contraindications for PDE5 inhibitors

pateints taking nitrates (greatly increases action of NO)

17

mechanism cypionate

slow release testosterone

esteryied fatty acid to 17 hydroxyl group makes lipophilic > ester hydrolysis is slow

19

slow release testosterone

cypionate

20

epiphyses,

bone density

lipido 

regualted at

estrogen receptor

21

5a-reductase antagonist 

finasteride

22

testosterone precursors popular as supplements

androstenedione

DHEA