Thyroid Path Flashcards Preview

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Flashcards in Thyroid Path Deck (17):
1

follicular carcnoma associated with ___ mutations

RAS oncogene

2

Grave's morphology

follicular cells are larger and  more crowded

irregular follicel contour

scalloped colloid

lined by tall columnar epithelium

2

anaplastic carcinoma morphology

agressive

invade structures of neck

pleomorphic giant tumor cells

spindle cells

3

thyroglossal duct cyst morphology

cyst lined by squamous or respiratory epithelium

thyroid tissue within walls of cyst

attached to hyoid bone (moves with swallowing)

3

papillary carcinoma morphology

papillary projections of large follicular cells

clearing orphan annie nuclei

psuedoinclusions

4

medullary carcinoma derived from

 

produce

C cells of thyroid

 

produce calcitonin

6

riedel thyroiditis morphology

 

clinically similar to 

extensive fibrosis involving thyroid and surrounding neck structures

 

similar to thyroid carcinoma

7

mody common malignant thyroid neoplasm

papillary carcinoma

8

hashimotos thyroiditis morphology

diffuse and symmetric enlargemnet of thyroid, possible nodules

 

massive infiltrate of lymphocytes with germinal centers

folicles atrphic with hurthle cell change (pink due to increased mitochondria)

8

Subacutethyroiditis (de Quervain thyroiditis)

 

morphology and presentation

destruction of thyroid with granulomatous inflammation, giant cells

colloid follicles

 

presents with pain and tenderness

9

medullary carcinoma morphology

 

associated mutations

nests and cords of cells in amorphous pink amyloid stroma

 

RET, MEN-2A or MEN-2B mutations

10

follicular adenoma morphology

benign, solid

capusle

unirform pattern of follcilces differing from surrounding thyroid

usually small colloid filled follicles

12

follicular carcinoma morphology

resembles follicular adenoma

(thin fibrous capsule, uniform pattern of small, colloid filledfollicles)

dx requires vascular or capsular invasion

14

noular goiter morphology

 

 

patients are typically ___

reflect ___-

multiple nodules of variably sized follicles

focally enlargedd with increased colloid, unencapsulated

 

patients typically euthyroid

reflects impaired synthesis of thyroid hormone (iodide def)

15

papillary carcinoma metastasis via

 

associated with

metatasis via lymph

 

associated with RET and BRAF mutations

16

follicular carcinoma metastasis via

blood

17

most common thyroid lesion

nodular goiter