Thyroid Path

Question 1

follicular carcnoma associated with ___ mutations

Answer 1

RAS oncogene

Question 2

Grave’s morphology

Answer 2

follicular cells are larger and more crowded

irregular follicel contour

scalloped colloid

lined by tall columnar epithelium

Question 2

anaplastic carcinoma morphology

Answer 2

agressive

invade structures of neck

pleomorphic giant tumor cells

spindle cells

Question 3

thyroglossal duct cyst morphology

Answer 3

cyst lined by squamous or respiratory epithelium

thyroid tissue within walls of cyst

attached to hyoid bone (moves with swallowing)

Question 3

papillary carcinoma morphology

Answer 3

papillary projections of large follicular cells

clearing orphan annie nuclei

psuedoinclusions

Question 4

medullary carcinoma derived from

produce

Answer 4

C cells of thyroid

produce calcitonin

Question 6

riedel thyroiditis morphology

clinically similar to

Answer 6

extensive fibrosis involving thyroid and surrounding neck structures

similar to thyroid carcinoma

Question 7

mody common malignant thyroid neoplasm

Answer 7

papillary carcinoma

Question 8

hashimotos thyroiditis morphology

Answer 8

diffuse and symmetric enlargemnet of thyroid, possible nodules

massive infiltrate of lymphocytes with germinal centers

folicles atrphic with hurthle cell change (pink due to increased mitochondria)

Question 8

Subacutethyroiditis (de Quervain thyroiditis)

morphology and presentation

Answer 8

destruction of thyroid with granulomatous inflammation, giant cells

colloid follicles

presents with pain and tenderness

Question 9

medullary carcinoma morphology

associated mutations

Answer 9

nests and cords of cells in amorphous pink amyloid stroma

RET, MEN-2A or MEN-2B mutations

Question 10

follicular adenoma morphology

Answer 10

benign, solid

capusle

unirform pattern of follcilces differing from surrounding thyroid

usually small colloid filled follicles

Question 12

follicular carcinoma morphology

Answer 12

resembles follicular adenoma

(thin fibrous capsule, uniform pattern of small, colloid filledfollicles)

dx requires vascular or capsular invasion

Question 14

noular goiter morphology

patients are typically ___

reflect ___-

Answer 14

multiple nodules of variably sized follicles

focally enlargedd with increased colloid, unencapsulated

patients typically euthyroid

reflects impaired synthesis of thyroid hormone (iodide def)

Question 15

papillary carcinoma metastasis via

associated with

Answer 15

metatasis via lymph

associated with RET and BRAF mutations

Question 16

follicular carcinoma metastasis via

Answer 16

blood

Question 17

most common thyroid lesion

Answer 17

nodular goiter