Testis and Paratesticular Adnexa Flashcards Preview

Endocrine > Testis and Paratesticular Adnexa > Flashcards

Flashcards in Testis and Paratesticular Adnexa Deck (29):
1

Germ cell role

dif to spermatids > spermatoza 

2

morphology lymphoma

white to tan fleshy tumor

interstital growth patter, spares seminiferous tuules

difuse large cell types with B cell phenottype

2

most common tumor of epididymis

 

derived from

adenomatoid tumor (always benign)

 

mesothelial origin

3

associaited conditions orchitis

TB

mumps

HIV

syphilis

extension from epididymitis

4

most common teste tumor in age >60

lymphoma

5

Sertoli cells role

support germ cell devo to spermatozoa

produce inhibin> spermatogenesis

Aromatize T into estradiol > spermatogenesis

5

second most common germ cell tumor

embryonla carcinoma

7

Prehn's sign

elevation relieves pain 

indication of epididmytis

8

Epididmytis assocations

gonorrhea,

chlamdia,

TB

E coli,

psuedomonas

8

markers and morphology choriocarcinoma

serum B-hcG elevated

multinucelated synctiotrophoblastic cells or intermediate trophoblasts

9

markers embryonal carcnoma

Serum AFP normal 

hCG up in 60% of cases

10

worse outcome in teratoma if

immature - contain immature neuroepithelium, blastema, carcinoid, or cellular stroma

11

typical findings in ITGCN

spermatogenesis abent in involved tubes

atypical with nuclear elargement and large nucleoli

aneuploid DNA

contains isochromosome 12p (like in seminoma)

12

non invasive precursor of germ cell tumors and testis (both seminoma and non-seminoma)

 

seen in cryptorchidism

Intratubular germ cell neoplasia (ITGCN)

12

papillary mesothelioma

 

papillary excrescenes in tunica vaginalis

hydrcele sac papillae lined by bland cells with large nuclei and nucleoli

13

morphology embryonal carcnoma

fleshy white grey tumor with prominent necrosis

large cells with vesticular nuclei, prominent nucleoili,

glandular structures 

15

cryptorchidism

 

later association

testes fail to respond in hCG dependent process

 

 

germ cell tumors 4-10 times more likely

16

spermatic cord vasitis nodosa

usually post vasectomy - transected end of vas deferens

 

sperm containing ductules commicnating wiht central lumen of vas deferens, extend into stroma

 

resembles invasive adenocarcinoma, preence of sperm, chroniic ifnlammation, lack of atypia differentiate

17

treatment for non-seminomatous germ cell tumors

chemosensitive, not radiosensitive (unlike seminoma)

18

most common germ cell tumor in children/infants

 

morphology

yolk sac tumor (endodermal sinus tumor)

white to gray masses

myxoid and cystic change 

Schiller Duval bodies - central vessel lined by loose connective tissue, in turn lined by malignat epithelium, all in a cystic space

19

main tumor marker for yolk sac tumor (endodermal sinus tumor)

elevated AFP

20

leydig cells produce ___ in response to ___

Testosterone in response to LH

21

most common metatases to testis

prostate cancer 

22

risk factors for testicular cancer

Cryptoorchid testicle (intra-abdominal is greatest risk)

Testicular feminization

Klinefelters syndrome XXY

24

seminoma markers

 

histo

a-fetoprotein 

B-human chorionic gonadtropin elevated

 

solid nests separated by fibrous spetae

lymphoid infiltrate

26

leydig cell tumor morphology

clear cytoplasm, no nesting

sheets or random arrangements

27

sertoli tumor morphology

closely packed cords

28

adenomatoid tumor morphology

circumstribed, grey-white 

29

Choriocarcinoma prognosis

poorer, metatasizes to lungs and brain

sensitive to chemo