Cervix vagina vulva path Flashcards Preview

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Flashcards in Cervix vagina vulva path Deck (23):
1

lichen simplex chronicus

secondary to chronic inflammation and itching

thikened hyperketatoic and white plaques

thikened epithelium with chronic inflammation

NO known prediliction for carcnoma

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1

invasive sqaumous cell carcinom of vaginaa preceded by 

vulvar dysplasia (VIN)

reactive  changes (lichen sclerosus)

1

HPV vaccine makeup

HPV l1 protein, th major capsid protein of HPV

3

sqaumocolumnar junction =

trasnformation zone

4

vulvar intraepithelial neoplasia (VIN) = 

precancerous lesion of vulva

high risk HPV

(VIN 1-3 depending on dysplasia)

progression to squamosu cell carcnionma

4

sqaumous cell dysplasia of vagina = 

VAIN (1-3)

possible porgression to squamous carcinoma

4

quadravalent HPV vaccine covers

6 11 16 18

5

extrammammary paget's disease =

red scaly plaques on labia

characterized by large pale glandular cells in epidermis

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6

dysplaysia in CIN characterized by 

nuclear atypia

ncreased N:C ratio abundant mytoses

7

cervical pap smear cytology screening begins at

21

cotesting with/without HIgh risk HPV after age 30

8

endocervical polyps morphology

glandular or metaplastic squamous lining

dilated glands with mucus

may blled (ulceration or infalmmation)

no malignnat potential 

8

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10

sarcoma botryoides (embryonal rhabdomyosarcoma) presentation and appearance

infants and young children

soft, polypoid masses in vagina

urinary bladder and bile ducts also possible

characterized by primitive cells

12

HPV pathogenesis

squamous cell strains replicated DNA ? express E6 and E7

E6 binds p53, E7 binds Rb > promote growth and carinogenesis

13

cervical polyps arise from

 

characterized by

arise from endocercvical glands

 

characterized by glandular or metaplastic squamous epithelium

15

ecto cervix epithelium

stratified squamous nonkeratinized

17

CIN is caused by ___

 

divisions of CIN

preceded by HPV

 

C1 - basal 1/3 of epeithelium dysplastic

CIN 2 = 2/3

CIN 3 = full thickness

18

carcinomal arising in endocervical glands

adenocarcinoma

20

vulvar strucutres that secerte mucus 

bartholin's glands

21

vulvitis = 

infection from bacterial, fungal or viral

 

nonspecific chronic inflammation of mucosal surfaces )vulvar vestibulitis)

22

Lichen sclerosus = 

premenarchal and post menopausal age group

pruritc and thin  papery skin

fibrotic dermis, loss of skin appendages, chronic inflam infiltrate

 

possible development of squamous cell carcinoma

23

clear cell carcinoma associated with

maternal DES expsoure

Vaginal adenosis can progress to clear cell carcinoma