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Flashcards in Prostate Deck (17):
1

Grade 3 prostate cancer

grade 4 

Grade 5

Grade 3 prostate cancer: small glands, infiltration, loss of double cell layer

grade 4: prominent nucleoli, non basement cells, fusion of glands 

Grade 5: single cells 

2

clinical findings in acute/chronic prostatitis

 

serum findings

Fever

lower back / perineal / suprapubic pain 

painful, swollen gland on rectal

dysuria, hematuria

 

elevated sserum PSA (>4.0)

2

Cancer prostate staging ("T"0

T1, T1a - incidental tumor in
T1b > tumor >5%

T2, T2a tumor in
T2b tumor in moree than half of one lobe, but not both
T2c tumor in left AND right lobe

T3, T3a: extraprostatic extension into fat
T3b invasion to one or both seminal veiscles

T4 invasion to near by structures

2

prostatic carcinoma spread

seminal veiscles

external iliac nodes

boney metastasis due to BAtson venous plexus (elevated prostatic alk phas, PSA increased)

possible compression of spinal cord

3

Chronic non bacterial prostatitis (chronic pelvic pain syndrome)

 

presentation and etiology

prostatitis without UTI or positiive cultures

 

Chlamydia trachomatis

Ureaplasma urealyticum

trihcomonas vaginalis 

3

histology granlulomatous prostatitis

 

chronic

 

aggregate of histiocytes (macrophages) 

 

chronic - inflammatory cells, glands

4

BPH is ____ dependent process

androgen (primarily DHT)

6

normal prostate cellualr morphology

double cell layer:

secretory cells and basal cells

7

causes of acute prostatitis

 

granulomatous

acute - intraprostate reflux, Rod bactera (E coli, aeruginosa, K pneumoniae)

 

granulomatous - instrumentation, bacille Calmette Guerin therapy for bladder cancer, others

9

area of BPH

transitional

10

indications for PSA screening

men over 50

Family Hx of Prostate CA

African AMericans

(increased risk screening begins at 40)

12

Dx chronic bacterial prostatitis

10-12wbc/field in secretions/urine

AND

positive bacterial cultures

12

causes granulomatous prostatitis

Infectious - Tuberculosis (hematogenous)

Fungal/mycotic (AIDS)

 

non infectious: Post surgical (biopsy rxn)

Post Bacille calmette guerin

non specific 

14

possible serum marker for BPH

elevated PSA

15

role of PSA

increases sperm motility

maintains semilar secretions in liquid state

protease formed by epithelial cells of prostate

16

prostatic precursor to invasive Cancer

 

does not raise PSA alone

High grade prostatic intraepithelial neoplasm HGPIN

17

zone of most cancer incidence

Peripheral