Female path Flashcards Preview

Endocrine > Female path > Flashcards

Flashcards in Female path Deck (11):
1

endometritis histo

plasma cells in endometrial stroma 

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2

mutations common in endometrial polyps

6p21

3

endometriosis presentation

cyclic bleeding

possible progression to chocolate cyts

blood leads to reactive changes, fibrosis, adhesions

4

endometriosis histo

endometrial glands + stroma

+ / - hemosiderin

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5

adenomyosis = 

 

histo

growth of endo metrium in myometrium > enlarged, nodular, abnormal bleeding 

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6

endometrial hyperplasia due to

 

histo 

prolonged exposure to estrogen - obesity, anovulation, estrogen producing tumors 

 

exagereated endometrial proliferation, glands:stroma >50%
abnormal gland architecture

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7

endometrial adenocarcinoma histo

back to back glands
cellualr atypia
abunant mitoses
necrosis 

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8

mutation in type 1 endometrial adenocarcinoma

mismatch repair gene HNPXX tumor supressor gene PTEN (Cowden sydrome)

9

type II endometria carcinoma histo+ findings

atrophic background

older women, more agressive
independent of endo hyperplasia 

atrophic glands

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10

leiomyma presentaion and histo

asymptomatic or abnl bleeding 
blacks>white
monoclonal prolif of smooth muscle
sharply demarcated 

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11

leiomyosarcoma histo and presentation

solitary, recurrence and metatasis common (pelvis, lung, bones)

post menopausal

denovo from myometrial mesenchymal cells
soft, hemorrhagic necrotic mass
cytological atypia and mitosis

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