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Endocrine > Female path > Flashcards

Flashcards in Female path Deck (11):
1

endometritis histo

plasma cells in endometrial stroma 

2

mutations common in endometrial polyps

6p21

3

endometriosis presentation

cyclic bleeding

possible progression to chocolate cyts

blood leads to reactive changes, fibrosis, adhesions

4

endometriosis histo

endometrial glands + stroma

+ / - hemosiderin

5

adenomyosis = 

 

histo

growth of endo metrium in myometrium > enlarged, nodular, abnormal bleeding 

6

endometrial hyperplasia due to

 

histo 

prolonged exposure to estrogen - obesity, anovulation, estrogen producing tumors 

 

exagereated endometrial proliferation, glands:stroma >50%
abnormal gland architecture

7

endometrial adenocarcinoma histo

back to back glands
cellualr atypia
abunant mitoses
necrosis 

8

mutation in type 1 endometrial adenocarcinoma

mismatch repair gene HNPXX tumor supressor gene PTEN (Cowden sydrome)

9

type II endometria carcinoma histo+ findings

atrophic background

older women, more agressive
independent of endo hyperplasia 

atrophic glands

10

leiomyma presentaion and histo

asymptomatic or abnl bleeding 
blacks>white
monoclonal prolif of smooth muscle
sharply demarcated 

11

leiomyosarcoma histo and presentation

solitary, recurrence and metatasis common (pelvis, lung, bones)

post menopausal

denovo from myometrial mesenchymal cells
soft, hemorrhagic necrotic mass
cytological atypia and mitosis