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Flashcards in Breast Path Deck (19):
1

__ changes in the breast is a risk factor for breast cancer

fibrocystic

2

In Situ carcinomas do not ____ and they proliferate where?

spread; in their original location

3

DCIS is a _ __ precursor of ___ ___

non-obligate; invasive carcinomas

4

DCIS show ___ ___ on path

calcified necrosis

5

Clinically, DCIS are __ (feature) and ___ (treatment)

benign; treatable

6

LCIS cells proliferate and destroy the original

lumen

7

LCIS are only seen __ on imaging

incidentally

8

LCIS frequently has __ __ cells on path

signet ring

9

LCIS treatment is ___ and __ (style) or ___ (drug) rather than mastectomy

watch and wait; tamoxifen

10

DCIS can be seen on a __ which is the most common way they're found

mammogram

11

__ disease of the ___ signifies an underlying breast cancer which has spread from the ducts to the skin of the nipple. Can be __ __ or __. Presents with a __ of the nipple

Paget; nipple; in-situ; invasive; crusting

12

__ breast carcinoma presents with reddening of the breast and is a serious form of cancer. There are no __ cells but cancer is seen in the __ lymphatics

Inflammatory; inflammatory; dermal

13

What does the TMN staging shorthand stand for?

Tumor size, metastasis, lymph nodes

14

Predictive markers look for what two receptors and why?

estrogen and progesterone, to predict response to anti-hormonal treatment

15

___ protein overexpression predicts response to __ (drug)

Her-2; trastuzumab

16

Oncotype DX tests work in patients with what 3 characteristics?

ER-positive, node-negative, and can withstand 5 years of tamoxifen

17

Oncotype DX low risk patients get no __; high risk groups get ___; the middle is unclear

chemo

18

__ syndrome is a risk factor for male breast cancer: so is the __ gene

Klinefelter (xxy); BRCA2

19

Male breast cancer is ___ only

ductal