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Flashcards in ED Deck (28):
1

Stress causes a ___ in testosterone in males

decrease

2

The preoptic, anterior and ventromedial nuclei of the hypothalamus are important for

male fertility

3

GnRH is made in the

preoptic anterior hypothalamus

4

Kallman syndrome (no GnRH production) patients have an altered sense of __ because GnRH neurons migrate from the ___ to the hypothalamus

smell; nose

5

Continuous release of GnRH causes a ___ of GnRH receptors because of the loss of the ___ and only having peaks

decrease; troughs

6

LH has a ___ half life and acts on LH receptors on __ cells

short; leydig

7

FSH has a __ half life and acts on FSH receptors on __ cells

long; sertoli

8

Testosterone is released from the __ cells and provides negative feedback to the ___ and the ___

leydig; hypothalamus; anterior pituitary

9

Estradiol is converted from testosterone by ___ and has a ___ negative feedback effect than testosterone

aromatase; stronger

10

Inhibin B acts on the __ to limit ___ secretion

anterior pituitary; FSH

11

Testosterone has a direct effect on (LH or FSH) secretion

LH

12

Exogenous testosterone ____ endogenous testosterone through ___ and __ sperm count through __

decreases; LH; decreases; FSH

13

Puberty causes __ surges of LH and FSH and __ the HPA axis sensitivity to steroids

nocturnal; resets

14

Testosterone production occurs in the ___ compartment

peritubular

15

What is the rate limiting step in the synthesis of testosterone and what protein is it done by?

The transport of cholesterol along the mitochondrial membrane; SAR

16

Only __% of testosterone is actually bioavailable

40

17

The major sign of hypogonadism in males is

testicular atrophy

18

Primary hypogonadism is a defect of the ___ themselves with very high __ and __ levels

testicles; FSH and LH

19

Secondary hypogonadism is a ___ defect

central

20

__ are an acquired form of hypogonadism due to hyperthermia of the scrotum

Varicoceles

21

The Hypothalamus has the __ which recognizes a sexual partner

MPOA

22

The PVN and the PGN do what to the erection

stimulate and inhibit respectively

23

The locus coeruleus is the __ center

integration

24

The sympathetics arise from T _ - __ and the PS arise from S_-_

10-12; 2-4

25

Projectile ejaculation is a skeletal muscle function done by the __ nerve

pudendal

26

ED drugs work on __ and require ___ to work

PDE-5; stimulation

27

ED often precedes __ disease

heart

28

Sexulation stimulation involves the __ pathway and the enzyme which non-sexual erection involves __

NO; PDE-; prostaglandins