Menopause Flashcards
(20 cards)
The primary driver of ovarian aging is the decline in the number of
follicles
Germ cells arrive at the genital ridge and begin to form at week
6
Ovaries differentiate at weeks, and oocytes (matured from oogonia) begin __ but then __
8-12; meiosis; arrest
Ovarian follicular formation begins at weeks
16-20
During birth the ovaries are __ with both ___ growth and atresia
active; follicular
The rate of follicular atresia becomes more rapid when?
10-15 years prior to menopause
Lower number of follicles results in irregular __ and lower rates of
cycles; pregnancy
Diagnosis of menopause comes after no ___ for a ___
periods; year
Menopause have higher levels of __ and lower levels of __
FSH and LH; estrogen due to loss of estrogen negative feedback on HPA axis
Women have lower rates but higher mortality of both __ and __
CVD; MI
Coronary and bone effects due to menopause are caused by
decrease in estrogen levels
25% of women will have hotflashes for more than _ years, but most average _ years
5; 5
Three major risk factors for menopausal women
smoking, race, obesity
Median age of menopause is between __ and __ years
50; 52
The hallmark treatment of menopausal treatment is
estrogen replacement therapy
Diagnosis of premature ovarian insufficiency is the same as ___ but you must do __ tests one month apart
menopause; two
Turner syndrome genetics
45 X
Both x chromosomes are required to ensure normal number/development of ___ so Turner syndrome patients have severe
oocytes; follicular atresia
Chemotherapy damages ___ follicles
primordial
__ agents like cyclophosphamide are the worst
alkylating
