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Flashcards in Menopause Deck (20):
1

The primary driver of ovarian aging is the decline in the number of

follicles

2

Germ cells arrive at the genital ridge and begin to form at week

6

3

Ovaries differentiate at weeks, and oocytes (matured from oogonia) begin __ but then __

8-12; meiosis; arrest

4

Ovarian follicular formation begins at weeks

16-20

5

During birth the ovaries are __ with both ___ growth and atresia

active; follicular

6

The rate of follicular atresia becomes more rapid when?

10-15 years prior to menopause

7

Lower number of follicles results in irregular __ and lower rates of

cycles; pregnancy

8

Diagnosis of menopause comes after no ___ for a ___

periods; year

9

Menopause have higher levels of __ and lower levels of __

FSH and LH; estrogen due to loss of estrogen negative feedback on HPA axis

10

Women have lower rates but higher mortality of both __ and __

CVD; MI

11

Coronary and bone effects due to menopause are caused by

decrease in estrogen levels

12

25% of women will have hotflashes for more than _ years, but most average _ years

5; 5

13

Three major risk factors for menopausal women

smoking, race, obesity

14

Median age of menopause is between __ and __ years

50; 52

15

The hallmark treatment of menopausal treatment is

estrogen replacement therapy

16

Diagnosis of premature ovarian insufficiency is the same as ___ but you must do __ tests one month apart

menopause; two

17

Turner syndrome genetics

45 X

18

Both x chromosomes are required to ensure normal number/development of ___ so Turner syndrome patients have severe

oocytes; follicular atresia

19

Chemotherapy damages ___ follicles

primordial

20

__ agents like cyclophosphamide are the worst

alkylating