Ovarian Cancer Flashcards Preview

Repro > Ovarian Cancer > Flashcards

Flashcards in Ovarian Cancer Deck (14):
1

Low grade endometrioid cancers are associated with these two mutations

PTEN, AIR1a

2

95% of type II ovarian cancers have __ mutations

p53

3

40% of epithelial ovarian cancers occur between age _ and _

40;60

4

The biomarker ___ is elevated in 80% of ovarian cancers in __ with higher stage

CA125; increases

5

Early screening for ovarian cancer has no __ __ unless a ___ algorithm is used

mortality benefit; multimodal

6

OVA-1 is not a __ ____, but can be used to determine ____

screening tool; referral to a gynecological oncologist

7

Hereditary ovarian cancer only accounts for __-___% of the cancer population, and the major heritable mutation is

10-15; BRCA

8

The treatment recommended for the BRCA mutation is to

have a risk-reducing surgery

9

___ inhibitors inhibit DNA repair and are used for patients with a BRCA mutation

PARP

10

___ therapy for advanced ovarian cancer may increase __, remove ___ cells, and change ____ _____ kinetics

Cytoreductive; vascularity; chemo resistant; tumor growth

11

The new goal for cytoreductive surgery is ___

R0- no gross residual disease

12

Having surgery before chemo increases

complication rate

13

Intraperitoneal therapy delivers chemo to the ___ directly via a port, and while it does come with increased risk of ___, the amount of drug delivered is ___ than traditional chemo

peritoneum; infection; higher than

14

Avastin is a ___ inhibitor and should be used with caution with patients getting any sort of ____

VEGF; procedure