Ovarian Cancer

Question 1

Low grade endometrioid cancers are associated with these two mutations

Answer 1

PTEN, AIR1a

Question 2

95% of type II ovarian cancers have __ mutations

Answer 2

p53

Question 3

40% of epithelial ovarian cancers occur between age _ and _

Answer 3

40;60

Question 4

The biomarker ___ is elevated in 80% of ovarian cancers in __ with higher stage

Answer 4

CA125; increases

Question 5

Early screening for ovarian cancer has no __ __ unless a ___ algorithm is used

Answer 5

mortality benefit; multimodal

Question 6

OVA-1 is not a __ ____, but can be used to determine ____

Answer 6

screening tool; referral to a gynecological oncologist

Question 7

Hereditary ovarian cancer only accounts for __-___% of the cancer population, and the major heritable mutation is

Answer 7

10-15; BRCA

Question 8

The treatment recommended for the BRCA mutation is to

Answer 8

have a risk-reducing surgery

Question 9

___ inhibitors inhibit DNA repair and are used for patients with a BRCA mutation

Answer 9

PARP

Question 10

___ therapy for advanced ovarian cancer may increase __, remove ___ cells, and change ____ _____ kinetics

Answer 10

Cytoreductive; vascularity; chemo resistant; tumor growth

Question 11

The new goal for cytoreductive surgery is ___

Answer 11

R0- no gross residual disease

Question 12

Having surgery before chemo increases

Answer 12

complication rate

Question 13

Intraperitoneal therapy delivers chemo to the ___ directly via a port, and while it does come with increased risk of ___, the amount of drug delivered is ___ than traditional chemo

Answer 13

peritoneum; infection; higher than

Question 14

Avastin is a ___ inhibitor and should be used with caution with patients getting any sort of ____

Answer 14

VEGF; procedure