Male Sex Hormones

Question 1

Testosterone is converted to the more potent 5-DHT by

Answer 1

5-alpha reductase

Question 2

An important co-activator of androgens is __ and it’s a target for hormone dependent male cancers

Answer 2

ARA70

Question 3

Esterification of testosterone results in ____ effects, while alkylation results in __ effects

Answer 3

agonist; anabolic

Question 4

Finasteride inhibits type __ ____

Answer 4

II 5-alpha reductase

Question 5

Receptor antagonism is used for male __ cancer

Answer 5

prostate

Question 6

65% of circulating testosterone is bound to

Answer 6

SHBG

Question 7

Testosterone conversion to estradiol occurs in which two tissues

Answer 7

liver and adipose

Question 8

Esterification at the ___ position and alkylation at the __ postion of testosterone provide potency and anabolic properties to synthetic steroids, respectively

Answer 8

17b; 17a (a for alkylation)

Question 9

Type I 5-alpha reductase is found in ____

Answer 9

sebaceous glands

Question 10

___ is a type II 5-alpha reductase inhibitor

Answer 10

Finasteride

Question 11

__ accumulates in BPH

Answer 11

5-DHT

Question 12

Finasteride also treats ____ because of the accumulation of 5-DHT in this area

Answer 12

male-pattern baldness

Question 13

utamide/nilutamide

Cyproterone acetate are all ___ receptor antagonists

Answer 13

testosterone