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Flashcards in Male Sex Hormones Deck (13):
1

Testosterone is converted to the more potent 5-DHT by

5-alpha reductase

2

An important co-activator of androgens is __ and it's a target for hormone dependent male cancers

ARA70

3

Esterification of testosterone results in ____ effects, while alkylation results in __ effects

agonist; anabolic

4

Finasteride inhibits type __ ____

II 5-alpha reductase

5

Receptor antagonism is used for male __ cancer

prostate

6

65% of circulating testosterone is bound to

SHBG

7

Testosterone conversion to estradiol occurs in which two tissues

liver and adipose

8

Esterification at the ___ position and alkylation at the __ postion of testosterone provide potency and anabolic properties to synthetic steroids, respectively

17b; 17a (a for alkylation)

9

Type I 5-alpha reductase is found in ____

sebaceous glands

10

___ is a type II 5-alpha reductase inhibitor

Finasteride

11

__ accumulates in BPH

5-DHT

12

Finasteride also treats ____ because of the accumulation of 5-DHT in this area

male-pattern baldness

13

utamide/nilutamide
Cyproterone acetate are all ___ receptor antagonists

testosterone