Central Monoaminergic Systems Flashcards Preview

Undeleted > Central Monoaminergic Systems > Flashcards

Flashcards in Central Monoaminergic Systems Deck (31):
0

Neurons utilizing monoamine transmitters are restricted to:

Midbrain
Pons
Medulla

1

_____ (3) play important roles in maintenance of mood and behavior

Seratonin
Norepinephrine
Dopamine

2

Raphe nuclei

Seratonin neurons clustered close to midline of midbrain, pons, medulla and upper spinal cord

3

Ascending serotonin system nuclei
Transmitted via ____ to thalamus, hypothalamus, amygdala, hippocampus and basal forebrain
Transmitted through ___ cerebral cortex

Midbrain and pontine dorsal raphe
Medial forebrain bundle
Internal capsule

4

Descending serotonin system nuclei
Transmitted from ___ to spinothalamic neurons in dorsal horn
Transmitted from ___ to motor neurons in spinal cord = ____system

Raphe magnus
Raphe obscurus
Raphespinal system

5

All receptors for serotonin are _____ receptors w/ 1 exception (___)

G-protein coupled
5-HT3

6

______ system command spinal cord CPGs

Corticospinal

7

____ system integrate CPG function

Reticulospinal

8

_____ regulate magnitude and timing of CPG

Seratonergic raphespinal neurons of the descending raphe obscurus pathway

9

5-HT is synthesized from ____
Broken down into ____ by ____

Tryptophan
5-HIAA
Monoamine oxidase (MAO)

10

5-HT3 is a ___ receptor

Ligand-gated cation channel

11

Removes serotonin from synapse

Serotonin reuptake transporter (SERT)

12

Serotonin syndrome caused by ___

hyperserotongergic state

13

Most important and largest cluster of norepinephrine producing neurons

Locus ceruleus in the pons

14

Locus ceruleus is part of the ___ system

direct arousal

15

3 parts of the direct arousal system

Tuberomammillary nucleus: histamine
Locus ceruleus: Norepi
Raphe nuclei: serotonin

16

NE synthesized from ___

tyrosine

17

Rate limiting enzyme in NE synthesis

Tyrosine hydroxylase

18

All NE receptors are ____

G protein coupled receptors

19

NE receptor subclasses

Alpha 1 and alpha 2 adrenergic receptors
Beta 1 and beta 2 adrenergic receptors

20

Alpha 1 antagonist

Lowers blood pressure
Reduce symptoms of PTSD

21

Alpha 2 agonist

Feedback suppress NE release
Lowers blood pressure
Used in ADHD

22

Beta 1 adrenergic receptors predominate in ___

cerebral cortex and heart

23

Beta 2 adrenergic receptors predominate in ___

Cerebellum and lungs

24

3 Dopamine pathways

1. Nigrostriatal pathway
2. Nesocorticolimbic pathway
3. Tuberoinfundibular pathway

25

Nigrostriatal pathway

Substantia nigra (pars compacta) --> dorsal striatum
Facilitates movement in basal ganglia circuits

26

Mesocorticolimbic pathways

Ventral tegmental area --> ventral striatum via medial forebrain bundle
Ventral tegmental area --> limbic cortices, amygdala, hippocampus via medial forebrain bundle

DA responds to rewards

27

Turberoinfundibular pathway

Arcuate nucleus --> median eminence

Inhibits pulsatile release of prolactin from lactotrope cells

28

Dopamine synthesized from ___

tyrosine

29

All DA receptors are ___

G protein coupled receptors

30

Dopamine and NE broken down by (2)

Monoamine oxidase (MAO)
Catechol-O-methyl transferase