Overview of Immune System Flashcards Preview

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Flashcards in Overview of Immune System Deck (14):
1

Primary lymphoid tissues

Bone marrow
Thymus

2

Secondary lymphoid tissues

Lymph nodes
MALT/GALT
Spleen

3

Reticulo-endothelial system (RES)

collection of macrophages that filters arterial (spleen), enteric (liver), and venous (lung) vascular systems

4

Ab that fetus can make

IgM
Can't cross placenta
Constant level throughout life

5

Can cross placenta --> passive immunity

IgG
Maternal IgG decreases after birth
Individual IgG increases after birth. Max at 2 y/o

6

Passed from mother to baby in breast milk

IgA

7

Risk of infection =

(Dose x Virulence)/Resistance

8

ID50 =

# of administered organisms required to cause clinical disease in 50% of animals

9

IS homeostasis set point shift
Horizontal shift to right

Greater risk of infection b/c less immune response = immunosuppression
Too little up-regulation

10

IS homeostasis set point shift
Horizontal shift to left

Less tolerance --> greater immune response
Too much up-regulation --> damage to host

11

IS homeostasis set point shift
Horizontal shift

Changes in immunosuppression/tolerance for same level of immune response

12

IS homeostasis set point shift
Vertical shift

Changes in intensity of immune response for same degree of injury or number of organisms

13

IS homeostasis set point shift
Vertical shift up

more inflammation and tissue damage

14

IS homeostasis set point shift
Vertical shift down

less inflammation and tissue damage