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Flashcards in Inflammatory Response Deck (25):
1

5 Steps of Inflammatory Response

1. Recognition of injurious agent
2. Recruitment of leukocytes
3. Removal of agent
4. Regulation (control of response)
5. Resolution (repair)

2

Extrinsic source of catalytic enzymes causes _____

Liquefactive necrosis

3

Intrinsic source of catalytic enzymes causes _____

Coagulative necrosis

4

What type of necrosis?
Cells aggregate of amorphous granular pink material
No tissue architecture, no cell outlines
Enclosed by distinctive border of inflammatory cells

Caseous necrosis

5

Type of extravascular fluid:
Low protein content, few cells

Transudate

6

Type of extravascular fluid:
Increased hydrostatic pressure w/o associated increased vascular permeability

Transudate

7

Type of extravascular fluid:
Predominantly albumin

Transudate

8

Type of extravascular fluid:
high protein content, some white and red cells

Exudate

9

Type of extravascular fluid:
Increased vascular permeability

Exudate

10

Type of extravascular fluid:
Irrespective of flow or pressure

Exudate

11

Type of extravascular fluid:
Associated inflammatory cells and cellular debris

Exudate

12

Cytokines in acute inflammation

TNF, IL-1, IL-6, chemokines

13

Cytokines in chronic inflammation

INF-gamma, IL-4, IL-5, IL-12

14

Classically activated macrophages produce:

INF-gamma
Pro-inflammatory

15

Alternatively activated macrophages are induced by:

IL-13, IL-4 made by T cells

16

Alternatively activated macrophages produce:

Anti-inflammatory pathway

17

Anti-inflammatory mediators

Lipoxin
NO
IL-10, TGF-beta

18

Initiating cytokines of stable tissues:

TNF, IL-6

19

Mediated GF of stable tissues:

HGF, EGF, TGF-alpha

20

Mediating GF of fibrogenesis:

TGF-beta**
PDGF
FGF
IL-1, IL-13

21

Granulation tissue

highly vascular tissue composed of small vessels, fibroblasts, few inflammatory cells

22

Granuloma

Inflammation characterized by epitheloid macrophages and giant cells

23

Fibrous

Containing fibroblasts and collagen

24

Fibrinous

Contain fibrin, insoluble protein derived from fibrinogen

25

Metalloproteinases (MMPs)
Produced by ____

Degrades collagen
Fibroblasts, leukocytes, some epithelial cells