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Flashcards in Skin Deck (38):
1

Layers of epidermis (deep to superficial)

Stratum Basale
Stratum Spinulosum
Stratum Granulosum
Stratum Corneum

2

Melanocytes and langerhans cells are found in ____

epidermis

3

____ make up of 90% of cells in epidermis.

Keratinocytes

4

Cells of the stratum basale are attached to the basement membrane by ____

hemidesmosomes

5

Keratinocytes of the stratum spinulosum and basale are attached to each other by ____

desmosomes

6

Cytoplasmic plaques of desmosomes composed of (2)

Plakoglobin
Desmoplakin

7

4 layers of basement membrane zone (superficial to deep)

Plasma membrane of basal keratinocytes
Lamina lucida
Lamina densa: type 4 collagen
Sub basal lamina

8

2 layers of dermis

Papillary dermis
Reticular dermis

9

Papillary dermis:
Made of ___
Contains (2)
Controlled by:

Loose connective tissue, mainly type 3 collagen
Meissner's corpuscles, vascular networks
Sympathetic nervous system

10

Reticular dermis:
Made of ___
Function:
Contains:

Dense irregular connective tissue, mainly Type I collagen
Strength and elasticity
Glands and hair follicles

11

Vater-Pacini corpuscles

Mediate sense of pressure
Not affected by anesthesia

12

Tyrosinase

converts tyrosine to melanin within melanosomes in melanocytes

13

Found everywhere on skin except palms and soles

Sebaceous glands

14

Found mainly in axillae and genital regions

Apocrine glands

15

Sebaceous glands are under __ control

endocrine

16

Apocrine glands are under __ control

adrenergic sympathetic innervation

17

Eccrine glands

sweat glands

18

Pilosebaceous unit

Hair + sebaceous gland

19

3 cycles of hair growth

Anagen: active growth phase
Catagen: growth arresting phase
Telogen: resting phase/shedding phase

20

Hyponychium

skin underlying free end of nail

21

3 major protein components of cornified envelope

Enzyme that catalyzes the crosslinks

Loricrin
Involucrin
Keratolinin
"LIK the envelope"
Transglutaminase 1

22

Major membraine lipids of stratum corneum

Ceramides
Tightly packed and highly impermeable to water

23

Lamellar granule or keratohyalin granule?
Membrane bound

Lamellar granule

24

Lamellar granule or keratohyalin granule?
Not membrane bound

Keratohyaline granule

25

Lamellar granule or keratohyalin granule?
Location: upper spinous layers

Both

26

Lamellar granule or keratohyalin granule?
Primary site of activity: Granular-cornified layer interface

Lamellar granule

27

Metabolically inert, enucleated cells formed from keratinocytes in the viable lower layers of the epidermis

Corneocytes

28

Lamellar granule or keratohyalin granule?
Primary site of activity: granular layer & cornified layer

Keratohyaline granule

29

Lamellar granule or keratohyalin granule?
Deliver precursors of stratum corneum lipids into intercellular space

Lamellar granule

30

Lamellar granule or keratohyalin granule?
Deliver free amino acids to outer layers of stratum corneum (filaggrin monomers)

Keratohyaline granule

31

Lipid content of lamellar granule function:

Maintain vapor barrier and signaling cell turnover

32

Filaggrin in cornified cells function:

Matrix protein that promotes aggregation of keratin filaments

33

Sweat secretion controlled by ____

hypothalamus

34

UVC =

200-290 ozone layer

35

UVB =

290-320 Burning ray

36

UVA =

320 - 400 Tanning ray

37

Present in dermis and induce immediate hypersensitivity response

Mast cell

38

Produce pro-inflammatory cytokines (IL-1) and express MHC class II antigens and intracellular adhesion molecules

Keratinocyte