Ch 45 Flashcards
(49 cards)
hormones
-chemical signals secreted into circulatory system
-communicate regulatory messages within body
-only target cells w/ receptors for that hormone
-assembled into regulatory pathways
-can stimulate release of a series of other hormones (last activates nonendocinr target cell: hormone cascade pathway)
-syntehis of sex hormones regulated by FSH and LH
2 systems coordinate communication between body
-endocrine
-nervous
endocrine system
-secrtes hormones that coordinate slower but longer acting repsonses in reproduction, development, energy metabolism, growth and behavior
nervous system
-conveys high speed electrical signals along neurons (which regulate other cells)
intercellular communication
ways signals are transferred between cells are classified by 2 criteria:
-type of secreting cell
-route taken by signal to reach target
endocrine signaling
-maintains homeostasis
-mediates responses to stimuli
-regulates growth and developmentn
-hormones secreted into extracellular fluids by endocrine cells reach target via blood stream
neurotransmitters
-secerted by neuron at synapse
-diffuse short distances
-bind to receptors on target cells
neurohormones
-in neuroendocrine signaling
-secreted by neuroscretory cells
-travel to target via bloodstream
pheromones
-how members of same species may communicate
-chemicals released into environ.
-functions:
-mark trails leading to food
-define territory
-warn predators
-attract mates
endocrine gland
-thyroid, thalamus, parathyroid, adrenal gland, pituritary
-where endocrine cells are grouped in ductless organs
-secrete hormones directly into surrounding fluid
-contrast w/ exocrine (diff. system, salivary glands, liver) which has ducts and secrete onto body surfaces or cavities
chemical class of hormones
-polypeptides (proteins and peptides); water soluble
-amines derived from amino acids (water soluble)
-steroid (lipid soluble)
-solubility depends on location of receptors inside or on surface of target cells.
-water and lipid soluble differ in paths
water soluble hormones
-don’t pass easily through membrane
-secreted by exocytosis
-travel freely in bloodstream
-bind to cell-surface receptors
lipid soluble hormones
-pass easily through cell membrane
-diffuse across cell membranes
-travel in bloodstream bound to transport proteins
-diffuse through the membrane of target cells
-response usually change in gene expression
signal transduction pathway
-initated by binding of hormone to its receptor
-leads to responses in cytoplasm, enzyme activation, or change in gene expression
epinephrine
-many effects in mediating body response to short term stress
-binds to plasma membrane of liver cells
-triggers release of messenger molecules that activate enzymes (result in release of glucose in blood stream)
effects of hormones
-depends on type of receptor (diff. effect from diff. receptor)
-different signal transduction pathways
in insects, molting and development controlled by combination of hormones
PTTH stimulus release of ecdysteroid from prothiacuc galnds
-juvenil hormone initiates larval characteristics
-ecdysone promotes (w/ juvenile hormone) molting and development (in absence of juvenile hormone)
negative feedback loop
Inhibits response by reducing initial stimulus
-which prevents excessive pathway activity
positive feedback loop
Reinforces a stimulus to produce an even greater response
insulin and glucagon (antagonistic hormones)
insulin: decreases blood glucose
-glucagon: increases blood glucose
diabetes mellitus
- best known endocrine disorder
-caused by a deficiency of insulin or decrease response to insulin
-elevated blood glucose levels
-type 1: insulin dependent, immune system destroys pancreatic beta cells
-type 2: non-insulin dependent, insulin deficiency or reduced response due to change of insulin receptors
hypothalamus
-receives info from nervous system initiates responses through endocrine system
-produces oxytocin and ADH
pituitary gland
-attached to the hypothalamus
-anterior/posterior
anterior pituitary gland
-makes and releases hormones under regulation of hypothalamus
-FSH: tetses and ovaries
-LH:
-TSH: thyroid
-ACTH: adrenal cortex
-Prolactin: mammary glands
-MSH: melanocytes
-GH: liver, bones, other tissues