CH.5 Flashcards
T or F: immunoglobulins are antibodies
T
where are the heavy chains located on an immunoglobulin
inner
where are the light chains located on an immunoglobulin
outer
where is the variable region on an immunoglobulin
top
where is the constant region on an immunoglobulin
bottom
does the Fc fragment bind to Ag
no
what part of the immunoglobulin plays an important part in effector functions
Fc fragment
what makes up the fab fragment
one light chain and 1/2 of heavy chain
what does papain digestion of immunoglobulin yield
2 fab fragments and an Fc portion
what does pepsin digestion of immunoglobulin yield
Fab 2 fragment and Fc portion in pieces
what makes the light chains
malignant plasma cells
what kind of chains are kappa and lambda
light
which immunoglobulin has kappa and lambda light chains
found in all immunoglobulin
what kind of heavy chain does IgG have
gamma
what kind of heavy. chain does IgM have
mu
what kind of heavy chain does IgA have
alpha
what kind of heavy chain does IgD have
delta
what kind of heavy chain does IgE have
epsilon
what kind of variation do isotope immunoglobulin have
H chain
what kind of variation do allotrope immunoglobulin have
constant regions
what kind of variation do idiotype immunoglobulin have
variable regions
where is the hinge region located
on heavy chain between CH1 and CH2
what allows flexibility and hydrophobic residues in the hinge region
proline
what are the direct functions of an Ab
neutralization, agglutination, and precipitation
