OTHER BLOOD GROUPS Flashcards
(138 cards)
1
Q
what chromosome are the lewis genes on
A
19
2
Q
what 3 sets of alleles control lewis ags
A
Lele, Sese, Hh
3
Q
what is produced if there is a Le gene inherited
A
Lea
4
Q
what lewis alleles do not produce products
A
le, h, and se
5
Q
what is produced if there is an Se gene
A
Leb
6
Q
what lewis phenotype are nonsecrators
A
Le(a+b-)
7
Q
if someone is sese can they still have Lea present in body fluids
A
yes
8
Q
what kind of lewis ags are found in secretions
A
glycoproteins
9
Q
what kind of lewis ags are found in plasma
A
glycolipids
10
Q
what kind of lewis ag do RBCs adsorb
A
glycolipids
11
Q
what gene produces fucosyltrnasferase
A
FUT3
12
Q
what lewis phenotype cannot express the Leb phenotype
A
hh
13
Q
what is the Bombay phenotype
A
hh
14
Q
what do pregnant women have as a lewis phenotype
A
Le(a-b-)
15
Q
what lewis phenotype do children have
A
Le(a+b+)
16
Q
when can the correct lewis phenotype be obtained
A
2-3 years
17
Q
what causes the loss of lewis ag expression on RBCs
A
abnormal lipid metabolism
18
Q
what lewis phenotype produces the most abs
A
Le(a-b-)
19
Q
what kind of immunoglobulin are lewis abs
A
IgM
20
Q
what neutralizes lewis abs
A
lewis + plasma
21
Q
what is the more common lewis abs
A
anti-Lea
22
Q
what kind of anti-Leb ab reacts when both Leb and H ags are present
A
anti-LebH
23
Q
what kind of anti-Leb ab reacts with Leb regardless of the ABO type
A
anti-LebL
24
Q
when does the lewis ab agglutinate
A
IS test phase
25
can lewis abs bind C'
yes
26
if a pt's lewis ab demonstrate hemolytic properties what kind of blood is given to them
Le ag neg blood
27
what chromosome is the P1 ag on
22
28
what chromosome is the GLOBE gene on
3
29
what gene produces the P ag
GLOBE
30
what chromosome is the Pk ag on
22
31
what P group ag is more common
P1
32
what is the null P phenotype
p
33
what ags are expressed for P1k phenotype
P1 and pk
34
what abs are produced from P1k phenotype
anti-P
35
what ags are expressed for P2k phenotype
pk
36
if the P1 ag is stored for a long time what happens to the ag strength
decreases
37
where is anti-p1 found
serum of P2 people
38
what kind of immunoglobin is anti-P1
IgM
39
what temp is best for anti-P1
low
40
what neutralizes anti-P1
hydrated cyst fluid
41
who has anti-P
P1k phenotype
42
what kind of immunoglobin are anti-P
IgG
43
what temp is best for anti-P
body temp and room
44
what kind of p group antibodies do paroxysmal cold hemoglobinuria pt have
auto anti-P
45
does auto anti-P bind C'
yes
46
who has anti-Pk
p individuals
47
what inhibits anti-Pk
hydatid cyst fluid
48
who has anti-P-P1-Pk
p individuals
49
what kind of immunoglobulin is anti-P-P1-Pk
IgM
50
does anti-P-P1-Pk bind C'
yes
51
what temp does anti-P-P1-Pk agglutinate
room temp
52
what ab do people with encwinococcus granulosis tapeworm and bird handlers developed
anti-P1
53
what kind of chain do I ags have
branched
54
what kind of chain do i ags have
straight
55
what I group ag do newborns have
i
56
what I group ag do adults have
I
57
I adult ag on cell = i ___ ag on cell
cord
58
what is the term for someone with less amount I adult ag on cells
I intermediate
59
is anti-I clinically significant
yes
60
what kind of immunoglobin is anti- I
IgM
61
what temp does anti- I react
RT
62
what ab do pts with mycoplasma pneumoniae develop
cold auto anti-I
63
what I group ab reacts with cord cells
anti-It
64
what kind of infections are associated with anti-i ab
IM and Epstein-barr virus
65
what kind of immunoglobin are MN
IgM
66
what kind of immunoglobin are Ss and U
IgG
67
what chromosome has genes that code for MNS
4
68
what do GYPA and GYPB code for
glycophorin A and B
69
what does GYP code for
M and N
70
what does GPB code for
S and s
71
does MNS ags show dosage
yes
72
what destroys M and N
proteolytic enzymes
73
where is U ag found
glycophorin B
74
what other ag is always present when S and s are inherited
U
75
T or F: U neg cells are very rare
T
76
what MNS phenotype has partial or complete deletion of GPA
Ena
77
what MNS phenotype has near-complete deletion of GYPA and GYPB
Mk
78
does anti-M and anti-N bind C'
no
79
where are kell ags located
on glycoprotein that is in RBC mmb
80
what chromosome are kell ag located on
7
81
what makes kell ags sensitive to treatment with sulfhydryl agents
they have a highly folded disulfide bonded region
82
K=
kell
83
k=
cellano
84
what ag is expressed with this phenotype: Ko/Knull
Kx
85
what chromosome is Kx gene located on
X chromosome
86
what kind of immunoglobin are kell abs
IgG
87
what chromosome is the Duffy blood group
1
88
what Duffy. phenotype provides protection from malaria
Fy(a-,b-)
89
what kind of malaria does Fy(a-,b-) protect against
P. vivax
90
T or F: the Duffy ags do not show dosage
F
91
what kind of immunoglobin are Duffy abs
IgG
92
what chromosome are the Kidd blood group system located on
18
93
what ags do Jka and Jkb alleles code for
Jk3
94
what is the phenotype of JkJk
Jk(a-,b-)
95
what blood group system do enzymes affect
Kidd
96
Bg ag is on what cell
WBC
97
The following phenotypes are written incorrectly except for:
a. Jk a +
b. Jka+
c. Jk a (+)
d. Jk(a+)
d
98
Which of the following characteristics best describes Lewis antibodies?
IgM, naturally occurring, do not cause HDFN
99
The Le gene codes for a specific glycosyltransferase that transfers a fucose to the N -acetylglucosamine on:
Type 1 precursor chain
100
What substances would be found in the saliva of a group B secretor who also has Lele genes?
H, B, Le a , Le b
101
Transformation to Le b phenotype after birth may be as
Le(a– b–) to Le(a+b–) to Le(a+b+) to Le(a– b+)
102
in what way do lewis ag change during pregnancy
Lea and Leb both decrease
103
A type 1 chain has:
The terminal galactose in a 1-3 linkage to subterminal N -acetylglucosamine
104
Which of the following genotypes would explain RBCs typed as group A Le(a+b–)?
A/A Lele HH sese
105
Anti-Le bH will not react or will react more weakly with which of the following RBCs?
Group A 1 Le(b+)
106
Which of the following best describes MN antigens and antibodies?
Well developed at birth, susceptible to enzymes, generally saline reactive
107
Which autoantibody specificity is found in patients with paroxysmal cold hemoglobinuria?
anti-P
108
Which of the following is the most common antibody seen in the blood bank after ABO and Rh antibodies?
anti-K
109
The null K o RBC can be artificially prepared by which of the following treatments?
DTT and glycine-acid EDTA
110
Which antibody does not fit with the others with respect to optimum phase of reactivity?
anti-P1
111
Which of the following Duffy phenotypes is prevalent in blacks but virtually nonexistent in whites?
Fy(a– b–)
112
Antibody detection cells will not routinely detect which antibody specificity?
Anti-Kp a
113
Antibodies to antigens in which of the following blood groups are known for showing dosage?
kidd
114
Which antibody is most commonly associated with delayed hemolytic transfusion reactions?
anti-Jka
115
Anti-U will not react with which of the following RBCs?
M+N– S– s–
116
A patient with an M. pneumoniae infection will most likely develop a cold autoantibody with specificity to which antigen?
I
117
Which antigen is destroyed by enzymes?
Fya
117
Which antigen is destroyed by enzymes?
Fya
118
The antibody to this high-prevalence antigen demon- strates mixed-field agglutination that appears shiny and refractile under the microscope.
Sd a
119
What red blood cell treatment can be used to differentiate between anti-D and anti-LW?
DTT
120
Which of the following has been associated with causing severe immediate HTRs?
anti- Vel
121
Which of the following antibodies would more likely be found in a black patient?
Anti-Cr a
Anti-At a
Anti-Hy
122
Which of the following antigens is not in a blood group system?
LKE
123
A weakly reactive antibody with a titer of 128 is neutralized by plasma. Which of the following could be the specificity?
anti-Ch
124
An antibody reacted with untreated RBCs and DTT- treated RBCs but not with ficin-treated RBCs. Which of the following antibodies could explain this pattern of reactivity?
anti-Ch
125
The following antibodies are generally considered clinically insignificant because they have not been associated with causing increased destruction of RBCs, HDFN, or HTRs.
Anti-Ch and anti-Kn a
126
Which antigen is the receptor for Haemophilus influenza?
AnWj
127
Which antigen is not absent or is weakened on RBCs of individuals with PNH?
Co a
128
Which of the following blood groups is carried on a structure that helps to maintain the RBC membrane integrity through interaction with protein band 4.1?
Ge
129
What is the name of the Knops system serologic null phenotype?
Helgeson
130
Which antigen when absent produces a null in the Dombrock system?
Gy a
131
Which antigens are strongly expressed on placental tissue, allowing for the adsorption of antibodies?
Cromer
132
Which antigen was returned to the 901 series because there was no determined linkage to the SMIM1 gene?
ABTI
133
The FORS blood group system was first thought to be part of what system due to the addition of N -acetylgalactosamine (GalNAc) to the P antigen?
ABO
134
What glycophorin expresses the MN CHO collection antigens that are associated with altered levels of sialic acid (NeuNAc) or GlcNAc?
GPA
135
What techniques can be used to remove the reactivity of Bg antigens?
EDTA/glycine-HCL, Platelet adsorption, and Chloroquine treatment
136
ABTI was thought to be classified with which antigen prior to it gaining system status?
Vel
137
The Jr(a–) phenotype is found more commonly in:
Japanese.
