Ch.7 Flashcards
(41 cards)
what enhances host defense mechanisms
complement
complement proteins are synthesized where
liver
where are C1 components produced
intestinal epithelial cells
where is factor D made
adipose tissue
def? inactive precursors
zymogens
T. or F: most of the complement proteins zymogens
T
what is the end product of complement
lysis of invading cell
what amplifies inflammatory reactors
complement
does vascular permeability increase or decrease during complement
increase
what kind of cells do complement recruit during inflammation
monocytes and neutrophils
what are the 3 pathways for complement
classical, lectin, and alternative
what activates complement in the classical pathway
Ag-Ab complex
what activates complement in the alternative pathway
pathogen surface agent
what activates complement in the lectin pathway
lectin binding to pathogen surface (carbohydrates)
what do complement fragments act as
opsonins
def? a substance that makes other cells more susceptible to phagocytosis
opsonin
what is the 1st stage of complement
recognition unit
what protein is involved in the recognition stage of complement
C1
once C1 is fixed what are the next proteins activated
C4, C2, and, C3
what proteins make up the activation unit
C4, C2, and C3
what proteins make up the activation unit
C4, C2, and C3
what is the most effective immunoglobulin of the classical pathway
IgM
why is IgM the most efficient in the classical pathway
because it has multiple binding sites
T or F: CRP, some viruses, mycoplasma, some gram – bacteria(E.coli) can also activate Classical Pathway
T
