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1

3 diseases caused by Chlamydial infection

Chlamydial urethritis, Lymphogranuloma venereum, Trachoma

2

3 diseases caused by Ricketsial infection

Rochey mountain spotted fever, Q fever, Typhus Fever

3

What kind of parasite is Chlamydiae

obligate intracellular parasites

4

Can Chlamydiae make their own ATP

NO

5

What does Chlamydiae infect?

epithelial cells of skin and mucous membranes

6

Chlamydiae replication cycle

spore like metabolically inert Elementary bodies enter the cell, become metabolically active, reticulate body, undergo repeated binary fission, burst and release daughter elementary body

7

3 types of Chlamydiae

Ch. Psittaci, Ch. Pneumoniae, Ch. Trachomatis

8

How do you get a Ch. Psittaci infection?

bird's disease- inhalation of dried bird's feces causes human infection, fever and pneumonia

9

How do you get a Ch. Pneumoniae infection?

communicable by aerosol- causes a typical pneumonia in humans

10

How do you get a Ch. Trachomatis infection?

only in humans- causes trachoma, genital tract infection, lymphogranuloma venereum

11

What is trachoma?

chronic infection of conjunctival mucous membrane- common in Africa and Asia- transmitted by fomites and fingers

12

Who is trachoma highly contagious in?

children- transmitted by fomites and fingers

13

What does late stage trachoma cause?

scarring of conjunctiva and opacities in cornea resulting in blindness

14

What does Type D-K chlamydiae cause?

STD of infection through birth canal- world wide distribution- occurs in higher socio-economic group

15

What does Chlamydial infection cause in new borns?

acute purulent conjunctivitis

16

What does Chlamydial infection cause in adult males?

urethritis which may progress to epidedymitis, proctitis or prostitis

17

What does Chlamydial infection cause in adult women?

causes cervicitis (inflammation of cervix) may progress to salphingitis @ PID often sterility/ectopic gestation

18

What syndrome may patients with genital tract infection develop?

Reiter's Syndrome

19

What does Ch. Trachomatis L group cause?

lymphogranuloma venereum (LGV)

20

What does LGV cause?

painful ulcers on genitals with inguinal node enlargement, no immunity

21

Lab diagnosis of chlamydial infection?

cause characteristic inclusion bodies in cells- Giemsa stain is used to stain urethral/conjunctival smears to demonstrate infection

22

Tests for lab diagnosis of chlamydial infection?

immunolflourescent test, DNA probe, ELISA

23

What treatment are all chlamydial infections susceptible to?

TC/ Doxy

24

Treatment of chlamydial infection STDS

Azithromycin

25

Treatment of Chlamydial ophthalmia neonatorum

Erythromycin

26

Prevention for Chamydia

no vaccination, erythromycin drops for new borns

27

Define Reiter's syndrome

an autoimmune condition that develops in response to an infection in a part of the body

28

Symptoms of Reiter's Syndrome

an inflammatory arthritis of large joints, inflammation of the eyes, urethritis

29

How is reactive arthritis (reiters syndrome) transmitted?

transmitted through sexual transmitted diseases

30

Define Ricketsiae

obligate intracellular organisms, lack co enzyme A, NAD, ATP