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1

types of non enveloped RNA viruses

polio virus, coxsaki virus, Hepatitis A, Rhino virus, Rota virus

2

Types of enveloped RNA viruses

influenza, measels, mumps, rubella, rabies, retro virus (HIV, HTLV)

3

What does Influenze virus cause?

flu epidemic/pandemic

4

3 serological types of influenza

A, B, C

5

Define envelop of influenza virus

has two types of spikes- hemaglutinin & Neuraminidase- the envelop protein determines type specificity

6

Other name for influenza virus

orthomyxovirus which interacts with mucin and has an 8 segmented genome

7

What is the present strain causing swine flu?

H1N1

8

Who is the influenza A virus present in?

humans- also in birds, chicken, sqine and horses-- sources for antigenic shift and pandemics

9

Who is the influenza B virus present in?

humans only!

10

Transmission of influenza

air born- respiratory droplets- group A- antigenic shift every 10/11 years- group B is antigenic shift yearly

11

When does the infection of influenza occur?

in winter months; restricted respiratory tract- systemic symptoms ar not due to viremia

12

What are systemic systems of influenza due to?

due to circuating cytokines

13

What gives immunity to influenza?

IgA, IgG

14

clinical features of influenza

24-48 hours-- will have fever, myalgia, sore throat, cough- sudden onset. Resolves spontaneously in 4-7 days

15

Treatment for influenza?

Zanamvir & Tamiflu- inhibits release of virus from cell- effective against A and B
Amantadin effective against A

16

What is the natural host of Measles

single serotype- humans are the natural host

17

Transmission of Measles

transmission by respiratory droplets- world wide distribution-

18

What stage is Measles highly contagious in?

prodromal stage- non infectious after development of rashes- cough and sneezing spread disease

19

How often does the Measles epidemic occur?

once in 2-3 years

20

Clinical features of Measles?

fever, photophobia, runny nose and cough- red spot with white center on buccal mucosa of oral cavity

21

Define development of rash in Measles

rashes develop on face and then spreads downwards- become brownish several days later

22

What affect can measles have on pregnant women?

still births in pregnant women- affords life long immunity

23

Complications of measles

encephalitis- very rare
Sub acute schlerosing Pan- can develop years later but rare

24

Lab diagnosis for Measles

NONE- diagnosed on clinical grounds

25

Is there an antiviral drug for Measles?

NO

26

Prevention of Measles

live attenuated vaccine- given at 15 months or later because before then vaccine will have no effect because maternal Abs still present

27

Define Mumps

single sero type- infects URT and blood spreads to parotid gland, testes, ovaries, pancreas and sometimes meningitis

28

Can you get mumps more than once?

NOPE

29

How is mumps transmitted?

through respiratory droplets- world wide distribution- peak incidence in winter

30

What percentage of children have mumps without symptoms and are therefore immune?

30%