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1

Types of spirochetes

treponema, borrelia, leptospira

2

What is a causitive organism for syphilis

Treponema pallidum

3

What does treponema pallidum look like?

thin walled flexible spiral roda with axial filaments which causes undulating movements

4

Is treponema pallidum grown in a culture?

NO- not grown in culture media/in cell culture

5

Transmission of Treponema pallidum

through intimate contact of skin and mucous membranes

6

Is treponema pallidum transmitted to fetus?

YES- through the placenta

7

How is Treponema pallidum related to the world?

world wide in distribution, increasing incidence, notifiable disease

8

Path of transmission of treponema pallidum

no toxins or enzymes produced. Not very invassive, not much inflammation

9

While treponema run a chronic course if not treated?

YES

10

How many stages of treponema pallidum>

3

11

Primary stage of treponema pallidum

organism multiply at site of infection- 2-10 weeks after inoculation, pt develops painless ulcer on genitals- heals spontaneously

12

Secondary stage of treponema pallidum

1-3 months later, pt develops papular rashed in palms and soles - verrucae like growth of skin + mucous membranes in genitals

13

what are condyloma lata rich in?

spirochetes

14

WHat is condyloma lata?

verrucae like growth on skin and mucous membranes of genitals

15

Will the secondary stage heal on its own?

YES

16

Part portion of people in second stage progress to third stage?

1/3

17

latent stage of 2nd stage

symptoms occur 2-3 years later

18

Tertiary stage of syphilius

granuloma formation on skin and bones, CNS manifestation, tabes dorsailes, CVS lesions

19

What is tabes dorsal is?

pt will have abnormal sensation in coordination of walking and loss of knee jerk

20

Define CVS lesions

aortitis and aneurism formation of ascending aorta

21

congenital syphilis

Organism transmitted through placenta and can cause this disease in children

22

features of congenital syphilis

depressed nose, notched teeth, interstitial keratits, nerve deafness

23

3 features of congenital syphilis are known as what...?

Hutchinson's triad

23

RPR test

rapid plasma reagin test- nonspecific antibodies (reagin) bind cardiolipin (Ag) and reagin is a mixture of IgG &IgM

24

WHen will the RPR test be positive and when will it be negative?

Positive in primary and secondary stages
Negative after treatment

25

When do you have false positives in RPR?

occurs in leprosy, Hep B/infectious mononucleosis

26

When do you have false negatives in RPR?

if Abs are in too high concentration and no flocculation can result

27

Specific Serological Tests are what?

immuno fluorescent or haemaglutinin tests

28

Treatment for syphilis

Pen G- single dose- affords total cure
for pts allergic to Penicillin, take TC/Erythromycin for prolonged period

29

What happens in the treatment of secondary syphilis with Penicillin ?

Because bacteria is so high, you will have a rxn- fever, chill, myalgia flu like symptoms because of all the dead bacteria - Jerish Herxheimer rxn