Flashcards in Lecture 12 Deck (58)
Types of spirochetes
treponema, borrelia, leptospira
What is a causitive organism for syphilis
What does treponema pallidum look like?
thin walled flexible spiral roda with axial filaments which causes undulating movements
Is treponema pallidum grown in a culture?
NO- not grown in culture media/in cell culture
Transmission of Treponema pallidum
through intimate contact of skin and mucous membranes
Is treponema pallidum transmitted to fetus?
YES- through the placenta
How is Treponema pallidum related to the world?
world wide in distribution, increasing incidence, notifiable disease
Path of transmission of treponema pallidum
no toxins or enzymes produced. Not very invassive, not much inflammation
While treponema run a chronic course if not treated?
How many stages of treponema pallidum>
Primary stage of treponema pallidum
organism multiply at site of infection- 2-10 weeks after inoculation, pt develops painless ulcer on genitals- heals spontaneously
Secondary stage of treponema pallidum
1-3 months later, pt develops papular rashed in palms and soles - verrucae like growth of skin + mucous membranes in genitals
what are condyloma lata rich in?
WHat is condyloma lata?
verrucae like growth on skin and mucous membranes of genitals
Will the secondary stage heal on its own?
Part portion of people in second stage progress to third stage?
latent stage of 2nd stage
symptoms occur 2-3 years later
Tertiary stage of syphilius
granuloma formation on skin and bones, CNS manifestation, tabes dorsailes, CVS lesions
What is tabes dorsal is?
pt will have abnormal sensation in coordination of walking and loss of knee jerk
Define CVS lesions
aortitis and aneurism formation of ascending aorta
Organism transmitted through placenta and can cause this disease in children
features of congenital syphilis
depressed nose, notched teeth, interstitial keratits, nerve deafness
3 features of congenital syphilis are known as what...?
rapid plasma reagin test- nonspecific antibodies (reagin) bind cardiolipin (Ag) and reagin is a mixture of IgG &IgM
WHen will the RPR test be positive and when will it be negative?
Positive in primary and secondary stages
Negative after treatment
When do you have false positives in RPR?
occurs in leprosy, Hep B/infectious mononucleosis
When do you have false negatives in RPR?
if Abs are in too high concentration and no flocculation can result
Specific Serological Tests are what?
immuno fluorescent or haemaglutinin tests
Treatment for syphilis
Pen G- single dose- affords total cure
for pts allergic to Penicillin, take TC/Erythromycin for prolonged period