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1

List DNA enveloped viruses

herpes, varicella, cytomegalo, ebstein-Barr, smallpox, Moluscum contagiosum, Hep B

2

List DNA non enveloped viruses

Adeno virus, HPV, Parvo

3

List RNA Enveloped viruses

influenze, measels, mumps, rubella, rabies

4

2 types of Herpes simplex

HSV 1, HSV 2

5

Where does herpes simplex multiply?

inside the nucleus of the host cell- notorious for latent infections

6

Transmission of Herpes simplex

contact through the skin- touch
HSV1 through saliva
HSV2 through sexual contact

7

pathogenesis of HSV

(blisters) virsuses replicate in skin and mucous membrane and produce vesicular lesions

8

Define latent stage for the HSV1

virus hides in trigeminal ganglion (5th cranial nerve)

9

define latent stage for the HSV2

becomes latent in limbo-sacral ganglions. Immunity is not powerful and hence reoccurrence can occur

10

What does HSV1 produce?

vesicular lesion above the waist, gingivostomatitis in children, herpes labialis, eye (corneal ulcers) , brain (encephalitis), blisters in fingers

11

What does HSV2 cause?

lesions below the waist, genital herpes, neonatal herpes

12

Is the HSV2 incidence rising in the US?

YES

13

How do you diagnose HSV?

ELISA test - identifies specific viral proteins/fluorescent antibody staining of infected cells

14

treatment of HSV?

acyclovir

15

is there a vaccine for HSV?

NO

16

What does Varicella- zoster virus cause?

chicken pox- primary disease and shingles is the recurrent lesion
disease is self limiting

17

Transmission of Varicella-zoster virus?

through respiratory droplets, direct contact- highly contagious in children- occurs world wide!
occurs when immunity is lower

18

Pathogenesis of Varicella-zoster virus?

enters through respiratory tract and spreads through blood to skin- multiply and produce rashes, nuclear inclusion bodies can be seen

19

Can zoster and chicken pox occur more than once?

Not usually, but it has happened

20

clinical features of chicken pox

fever, malaise for 2 or 3 days followed by papulo vasicular rashes then spread to head and limbs

21

Development of crusts

papules--vesicles--pustules--crusts

22

Clinical features of Zoster

painful vesicles on the course of the spinal nerve/trigeminal nerve

23

Treatment for chicken pox?

no drugs necessary, self limiting

24

What will giving asprin produce in someone with chicken pox?

may produce Ryes syndrome- encephalopathy and liver damage

25

Treatment for shingles?

acyclovir/velacylovir

26

Prevention of varicella-zoster virus

vaccine- live attenuated vaccine

27

What does Cytomegalo virus cause?

congenital abnormalities in newborns- mostly mental retardation

28

How is Cytomegalo virus spread?

in children- through saliva
in adults- through semen/cervical secretions
in pregnant women- through placenta, breast milk, birth canal

29

What is the infection of cytomegalo in women and children?

mostly asymptomatic

30

What will infection of Cytomegalo in mothers during first trimester cause?

microcephaly- small head