Flashcards in lecture 15 Deck (70)
List DNA enveloped viruses
herpes, varicella, cytomegalo, ebstein-Barr, smallpox, Moluscum contagiosum, Hep B
List DNA non enveloped viruses
Adeno virus, HPV, Parvo
List RNA Enveloped viruses
influenze, measels, mumps, rubella, rabies
2 types of Herpes simplex
HSV 1, HSV 2
Where does herpes simplex multiply?
inside the nucleus of the host cell- notorious for latent infections
Transmission of Herpes simplex
contact through the skin- touch
HSV1 through saliva
HSV2 through sexual contact
pathogenesis of HSV
(blisters) virsuses replicate in skin and mucous membrane and produce vesicular lesions
Define latent stage for the HSV1
virus hides in trigeminal ganglion (5th cranial nerve)
define latent stage for the HSV2
becomes latent in limbo-sacral ganglions. Immunity is not powerful and hence reoccurrence can occur
What does HSV1 produce?
vesicular lesion above the waist, gingivostomatitis in children, herpes labialis, eye (corneal ulcers) , brain (encephalitis), blisters in fingers
What does HSV2 cause?
lesions below the waist, genital herpes, neonatal herpes
Is the HSV2 incidence rising in the US?
How do you diagnose HSV?
ELISA test - identifies specific viral proteins/fluorescent antibody staining of infected cells
treatment of HSV?
is there a vaccine for HSV?
What does Varicella- zoster virus cause?
chicken pox- primary disease and shingles is the recurrent lesion
disease is self limiting
Transmission of Varicella-zoster virus?
through respiratory droplets, direct contact- highly contagious in children- occurs world wide!
occurs when immunity is lower
Pathogenesis of Varicella-zoster virus?
enters through respiratory tract and spreads through blood to skin- multiply and produce rashes, nuclear inclusion bodies can be seen
Can zoster and chicken pox occur more than once?
Not usually, but it has happened
clinical features of chicken pox
fever, malaise for 2 or 3 days followed by papulo vasicular rashes then spread to head and limbs
Development of crusts
Clinical features of Zoster
painful vesicles on the course of the spinal nerve/trigeminal nerve
Treatment for chicken pox?
no drugs necessary, self limiting
What will giving asprin produce in someone with chicken pox?
may produce Ryes syndrome- encephalopathy and liver damage
Treatment for shingles?
Prevention of varicella-zoster virus
vaccine- live attenuated vaccine
What does Cytomegalo virus cause?
congenital abnormalities in newborns- mostly mental retardation
How is Cytomegalo virus spread?
in children- through saliva
in adults- through semen/cervical secretions
in pregnant women- through placenta, breast milk, birth canal
What is the infection of cytomegalo in women and children?