Chapter 19: Blood Flashcards
(90 cards)
1
Q
What is blood?
A
It is fluid connective tissue
2
Q
2 components of fluid connective tissue
A
- cells
2. plasma (matrix or ground substance)
3
Q
5 functions of blood
A
- Transportation
- Regulates pH and ion composition
- Prevents blood loss
- Defense against toxins and pathogens
- Stabilizes body temp
4
Q
What does blood transport?
-4 things
A
- Gases
- Nutrients
- Hormones
- Waste products
5
Q
What does regulating pH and ion composition help to maintain?
-Neutralize?
A
- Maintains K+ or Ca++ in tissues
- neutralizes lactic acid generated by muscle tissue
6
Q
How does blood prevent blood loss?
A
By clotting
7
Q
What in blood is known as defense?
-2 things
A
- White blood cells
2. antibody
8
Q
How does blood stabilize body temp?
A
Absorbs heat generated by muscle tissue and redistributes it
9
Q
Sample of whole blood consists of 2 things
A
- plasma
2. formed elements
10
Q
what 3 things does formed elements consist of
A
- RBC
- WBC
- Platelets
11
Q
Red blood cells are known as?
-White blood cells are known as?
A
- erythrocytes
2. leukocytes
12
Q
pH level in blood
- average
- range
A
- 7.4
- 7.35-7.45
13
Q
Blood temp
- celcius
- Fahrenheit
A
- 38C
- 100.4F
14
Q
Viscocity of blood
- meaning
- how much
A
- thickness
- 5x as viscous as water
15
Q
Salt concentration of blood
A
0.9% sodium chloride
16
Q
Percent of body weight
A
7%
17
Q
Volume of blood
- female
- male
A
- 4-5 L
- 5-6 L
18
Q
Centrifugation of blood allows
A
separation of plasma and formed elements
19
Q
How is blood collected
A
by venipuncture
20
Q
Buffy coat
- definition
- what does it contain
A
- small semi clear layer directly above packed RBCs
- WBCs and platelets
21
Q
Hematocrit
- definition
- formula
A
- % of formed element in a volume of whole blood
- volume of packed RBCs/volume of whole blood x 100
22
Q
Hematocrit in
- males
- females
- changes
A
- 46 (range 40-54) because of testosterone
- 42 (range 37-47)
- Dehydration, internal bleeding, problems with RBC formation
23
Q
Composition of plasma
A
- water (92%)
- plasma proteins (7%)
- other solutes (1%)
24
Q
Plasma proteins
- how much percent are made and secreted by the liver
- 4 proteins
A
- 90%
1. albumins
2. globulins
3. fibrinogen
4. regulatory proteins
25
Albumins
- percent
- abundance?
- function
- 60%
- most abundant
- transports fatty acid, thyroid hormones, some steroid hormones and other substances
26
globulins
- percent
- what are they?
- function
- 35%
- antibodies-immunoglobulins
- transport globulins - bind small ions, hormones and compounds
27
fibrinogen
- percent
- important for
- converted to
- what does it form
- 4%
- blood clotting
- converted to fibrin
- forms long strands for blood clotting
28
Regulatory proteins
- percent
- includes 2 things
-
29
3 Glycoproteins
1. TSH
2. FSH
3. LH
30
Other solutes
- percent
- 3 things
- 1%
1. Electrolytes
2. Organic nutrients
3. organic wastes
31
Electrolytes
| -8
1. Na+
2. K+
3. Ca 2+
4. Mg 2+
5. Cl-
6. HCo3-
7. HPO4-
8. SO4 2-
32
Organic nutrients
- what is it used for
- 3 things
- ATP production, growth and maintenance of cells
| - lipids, carbs and AA
33
Organic wastes
| -5 wastes
1. urea
2. uric acid
3. creatinine
4. bilirubin
5. ammonium ions
34
How much percentage does erythrocytes account for of formed elements?
99.9%
35
How many RBCs do we have per mm3 of blood?
- males
- females
- why is it different?
- 4.5-6.3 million/mm3
- 4.2-5.5 million/mm3
- because RBC formation is affected by androgens and not by estrogens
36
What is the structure of an erythrocyte?
bi-concave disc
37
Structure allows for 3 important effects on RBC function
1. give each RBC a large surface area to volume ratio
2. enables RBCs to form stacks
3. enables RBCs to bend and flex when entering small capillaries
38
RBC
- lifespan; why?
- function
- 120 days because in lacks a nucleus and ribosome prevents synthesis of new proteins (unable to repair itself)
- carry O2 to tissues and remove CO2 which is carried on molecules of hemoglobin
39
Anemia
Any condition when the quantity of RBCs is lower than normal
40
Polycythemia
Any condition when the quantity of RBCs is higher than normal
41
Hemoglobin
- percent of RBCs intracellular protein
- number of protein chains
- number of heme groups
- 2 functions
- 95%
- 4 (2 alpha and 2 beta)
- 4 (a ring containing iron)
- 1. Iron in heme group interacts with O2
2. The alpha and beta chains interact with CO2
42
1 heme = how many O2
1
43
- High plasma levels of O2
| - Low plasma levels of O2
- Hb binds O2
| - Hb releases O2
44
Oxyhemoglobin
- compound
- definition
- color
- HbO2
- O2 bound to heme group
- bright red
45
Deoxyhemoglobin
- definition
- color
- heme group not bound to O2
| - Dark red, burgundy in color
46
Carbaminohemoglobin
- compound
- definition
- HbCO2
| - CO2 bound to alpha and beta chains
47
Erythropoiesis
- definition
- occurrence
- fetal period
- adult
- formation of red blood cells
- appears during 3rd week of development
- begins in yolk sac
- occurs exclusively in red bone marrow
48
Where is red bone marrow found?
| -7 places
1. vertebrae
2. sternum
3. ribs
4. skull
5. scapula
6. pelvis
7. proximal limb bones
49
Erythropoiesis stages
| -4 stages
1. myeloid stem cell
2. proerythroblast
3. reticulocyte
4. mature red blood cell
50
is the myeloid stem cell only for red blood cells?
no
51
Reticulocyte contains
80% of Hb found in a mature RBC
52
3 requirements for normal RBC development
1. amino acids
2. iron
3. vitamins (B12, B6 and folic acid)
53
What does B12 require
an intrinsic factor in order to be absorbed by small intestine
54
what hormone is required for the regulation of RBC development?
-3 others
- Erythopoietin
| - thyroxine, androgens and growth hormone
55
where is erythopoietin made
in the kidneys
56
When in erythropoietin released?
- 4
- what do all of these result in?
1. During anemia
2. when blood flow to kidneys decline
3. O2 content of air in lungs decline
4. respiratory surface of lungs is damaged
- an overall decline in the O2 content of blood
57
2 effects when erythropoietin is released
1. stimulates increased cell division of erythroblasts
| 2. speeds up maturation of RBCs
58
```
RBC degradation (breakdown)
- Macrophage 10 steps
```
1. RBC undergoes phagocytosis
2. RBC is converted to hemoglobin (lysosome digests RBC)
3. Hemoglobin is broken down into protein chains and is converted to heme + globin (lysosome digests RBC)
4. Globin is converted to AA (lysosome digests RBC)
5. Heme is converted to biliverdin (green) OR the iron is released and transported through circulation
6. Biliverdin is converted to bilirubin (yellow)
7. Bilirubin is transported to liver through circulation
8. Bilirubin is secreted in bile to small intestine and travels to large intesting
9. bilirubin is converted to bilirubin derived products by bacteria and can go 2 ways ( to kidney or stay on the path of the large intestine)
10. Converted to urobilins stercobilins (yellow and brown) and turned into feces OR bilirubin derived products is absorbed into circulation, into kidney converted to urobilins (yellow) and turned into urine
59
RBC breakdown Hemolysis
| -2 steps
1. RBC
| 2. 10% is hemolysized
60
Percentage of RBC engufled while undergoing macrophage
90%
61
Where is macrophage found?
| -3 places
liver, spleen or bone marrow
62
4 blood groups
1. Type A
2. Type B
3. Type AB
4. Type O
63
antigen location
on surface of RBC
64
antibody location
found in blood plasma
65
Type A
- distribution in the US pop
- Antigen
- antibody
- 40%
- has antigen A
- Has anti - B antibodies
66
Type B
- distribution in the US pop
- Antigen
- antibody
- 10%
- has antigen B
- has anti-A antibodies
67
Type AB
- distribution in the US pop
- Antigen
- antibody
- 4%
- has both antigen A and B
- has no antibodies
68
Type O
- distribution in the US pop
- Antigen
- antibody
- 46%
- has neither antigen A or B
- has both anti A and anti-B antibodies
69
Agglutination
clumping; "likes" clump
1. You do not make antibodies that bind to antigens on your RBC
2. You make antibodies against antigens that are absent from your RBC
70
How do you find a compatible blood type for blood transfusions?
by cross matching recipients antibodies (plasma) to donor's antigens (cells)
71
What are we concerned about when transfusing blood?
the recipients antibodies
72
Rh factor
- where are the Rh antibodies not normally found
- when will Rh antibodies form
- where was it discovered
- if an Rh protein is present is Rh - or +; percentage of pop
- if the Rh protein is not present is Rh - or +; percentage of pop
- in plasma
- when an Rh- person is exposed to Rh+ blood (in transfusion or pregnancy)
- surface antigen 1st discovered in Rhesus monkeys
- Rh+ ( ~85%)
- Rh- (~15%)
73
Hemolytic disease of the newborn
- definition
- Rh+ mom and Rh- fetus =
- 3 steps (mom Rh- and fetus Rh+)
- moms antibodies (Rh+) attack fetal RBCs
- no problems
- 1. moms blood is exposed to fetal blood during the delivery process (1st pregnancy)
2. mom produces antibodies to Rh+ fetal blood (1st)
3. moms Rh antibodies generated after 1st pregnancy cross the placenta and attacks fetal RBCs (can be fatal if not treated)
74
Prevention of second pregnancy attacks
provide drug RhoGam during prenancy to prevent Rh antibodies from forming in mom
75
Leukocytes
| -4 general properties
1. less numerous than RBCs (5000 - 10000 / mm3)
2. have a nucleus
3. no hemoglobin
4. defense - immunity
76
where is the majority of leukocytes found?
in tissues; they squeeze through blood vessel walls through diapedesis
77
what are the leukocytes attracted by?
chemical stimuli known as chemotaxis
78
classification of RBC
| -2 major groups
1. granular leukocytes
| 2. agranular leukocytes
79
Granular leukocytes
- defintion
- 3 examples
- contains large cytoplasmic granules
- 1. neutrophils
2. eosinophils
3. basophils
80
Agranular leukocytes
- definition
- 2 examples
- do not contain large cytoplasmic granules
- 1. monocytes
2. lymphocytes
81
Neutrophils
- percentage
- thin or dense nucleus
- number of lobes
- color of granules
- mobile or motionless
- function
- lifespan
- known as
- 50-70%
- dense semented nucleus
- 3-5 lobes (beads on a string)
- pale
- highly mobile (first responders)
- attack and digest bacteria labeled with antibodies
- very short lifespan (30 minutes to 10 hours)
- polumorphonuclear leukocytes
82
Eosinophils
- percentage
- contain what type of nucleus
- color of granules
- what do they release
- when do they increase in number
- function
- 2-4%
- bi-lobed nucleus
- deep red granules
- release toxic compounds that kill multi cellular parasites
- during allergic reactions
- help reduce debris and spread of inflammation
83
Basophil
- percentage
- how many granules
- shape of nucleus
- migrate to where
- release what 2 things
-
84
Monocyte
- percentage
- shape of nucleus
- 3 functions
- 2-8%
- large oval/kidney bean shaped nucleus
- 1. enters peripheral tissues to become a macrophage
2. phagocytosis
3. release chemicals to attract neutrophils and monocytes
85
Lymphocytes
- percentage
- nucleus
- 2 functions
- known as
- 20-30%
- large nucleus surrounded by thick halo of cytoplasm
- 1. migrate through blood into tissues and back
2. defend against specific pathogens
- T and B cells
86
Production of platelets
| -4 steps
1. hemocytoblasts
2. myeloid stem cells
3. progenitor cells
4. megakaryocyte
5. platelets
87
production of granulocytes
| -8 steps
1. myeloblast
2. myelocyte
3. band cells
4. granulocytes
88
productions of monoblast
| -6 steps
1. hemocytoblasts
2. myeloid stem cells
3. progenitor cells
4. blast cells (monoblast)
5. promonocyte
6. monocyte
89
production of lymphocytes
| -5 steps
1. hemocytoblasts
2. lymphoid stem cells
3. lymphoblast
4. prolymphocyte
5. lymphocyte
90
Regulation of WBC production
- CSF (meaning and definition)
- what regulates lymphocyte
- Colony stimulating factors; stimulates production of monocytes and granulocytes
- exposure to antigen
