Chapter 24

Question 1

Define oncogenic

Answer 1

Cancer-causing

Question 2

Define teratogenic

Answer 2

Can cross placenta and cause damage to fetus

Question 3

What are the DNA enveloped viruses?

Answer 3

Poxviridae, Herpesviridae, and Hepadnaviridae

Question 4

What are the DNA naked viruses?

Answer 4

Adenoviridae, Papillomaviridae, Parvoviridae

Question 5

What are the RNA naked viruses?

Answer 5

Picornaviridae, Caliciviridae, Hepeviridae. Reoviridae

Question 6

What is caused by Poxviridae?

Answer 6

Smallpox and molluscum contagiosum

Question 7

What is smallpox?

Answer 7

A DNA enveloped virus, which has now been eradicated by vaccine. Causes rash

Question 8

Reservoir of smallpox?

Answer 8

Human

Question 9

Transmission of smallpox?

Answer 9

Respiratory

Question 10

Family of smallpox?

Answer 10

Poxviridae

Question 11

Types of smallpox?

Answer 11

Variola major and variola minor

Question 12

Last case of Variola major?

Answer 12

1975, Bangladesh

Question 13

Last case of Variola minor?

Answer 13

1977, Somalia

Question 14

Who is Jenner/what is he associated with?

Answer 14

Cowpox/smallpox

Question 15

What is molluscum contagiosum?

Answer 15

Monkeypox and cowpox

Question 16

What is Herpesviridae?

Answer 16

A DNA enveloped virus.

8 different types (2 are combined for our class, so 7 separate kinds)

Lasts forever, latent, can reactivate

Question 17

What is HHV-1?

Answer 17

Cold sores. Spread via saliva. Trigeminal/cranial nerve #5, can reactivate on lips or eyes

Can cause encephalitis in babies

Question 18

What is Herpetic kratitis?

Answer 18

Herpes in eye

Question 19

What is Herpes labialis?

Answer 19

Cold sores

Question 20

What is HHV-2?

Answer 20

Genital herpes. Sexual transmission
Sacral/lumbar region latency
Can be spread without visual lesions.

Question 21

What do HSV-1 and HSV-2 have in common?

Answer 21

Both can be reactivated by stress, fever, injury, and UV radiation. And both can damage a baby, requiring C-section

Question 22

What is HHV-3?

Answer 22

VZV, or Varicella-Zoster virus.
Varicella - chickenpox
Zoster - shingles
DNA enveloped virus
Vaccine exists!
Chickenpox is a prerequisite for shingles
Rash - trunk -> head -> extremities

Question 23

What type of pox is not a Poxviridae?

Answer 23

Chickenpox, it is a Herpes

Question 24

How is chickenpox/shingles transmitted?

Answer 24

Respiratory/reactivation

Question 25

What is HHV-4?

Answer 25

EBV, or Epstein-Barr virus. DNA enveloped virus Causes infectious mono and Burkitt's lymphoma Spread via saliva By mid-life, 90-95% people have been exposed

Question 26

What is infectious mononucleosis?

Answer 26

AKA kissing disease, causes EBV or Epstein-Barr virus. Caused by HHV-4 Latent in B cells. Fever, sore throat, spontaneous recovery 2-3wks

Question 27

What is Burkitt's lymphoma?

Answer 27

Caused by HHV-4. Cancers of lymphoid origin. Occurs due to coinfection of mono and another infection. Common in African children 4-8 y/o

Question 28

What is HHV-5?

Answer 28

CMV, or cytomegalovirus DNA enveloped virus Mono-like symptoms, congenital abnormalities Spreads through ANY bodily fluids Cells grow large 80% of adults in U.S. have antibody

Question 29

What is HHV-6 and HHV-7?

Answer 29

DNA enveloped virus. Causes roseola. Fever, rash in babies 2-12 months. Latent in B + T Cells

Question 30

What is HHV-8?

Answer 30

AKA KSHV, or Kapsosi's sarcoma. DNA enveloped virus. Sexual transmission. Causes purple patches all over skin from collection of RBCs. Common cause of cancer in AIDS patients, became more aggro due to weakened immune systems

Question 31

What is Hepadnaviridae?

Answer 31

DNA enveloped virus. Causes HBV/Hepatitis B Replicates in liver Many forms of transmission Causes cancer of liver Jaundice, rash, etc. 3 doses of vaccine prevent it Blood, sex, vertical transmission

Question 32

What is Adenoviridae?

Answer 32

DNA naked virus. Causes adenoviruses. Some respiratory, some fecal-oral

Question 33

What is Papillomaviridae?

Answer 33

DNA naked virus Causes HPV Direct contact transmission Warts (seed, plantar, genital) 16 and 18 cause cancer Cervical and penile cancer, pap smear for women 14mil new cases/yr

Question 34

What is vaccination for HPV like?

Answer 34

3 vaccines exist, but Gardasil 9 is the only one still used in the U.S. Harald Hausen linked HPV 16 and 18 with cancer

Question 35

Scientists of this chapter?

Answer 35

Harald Hausen - HPV 16 and 18 with cancer Jenner - smallpox/cowpox

Question 36

What is Parvoviridae?

Answer 36

DNA naked virus. Single-stranded! Also called B19 Causes erythema infectiosum Fifth disease Slapped cheek syndrome Can lead to hydrops fetalis - death/abortion of fetus Respiratory/transplacental transmission