Flashcards in Chronic myeloproliferative disorders Deck (4)
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1
Q
Polycythemia Vera
A
Abnormal clone of hematopoetic stem cells with constituitively active JAK2 receptors, proliferative w/o EPO stimulation; often presents as intense itching after hot shower
Increased RBCs, Increased WBCs, Increased platelets; JAK2 mutation positive
2
Q
Essential thrombocytosis
A
Specific for megakaryocytes
Increased platelets; Positive JAK2 mutation in 30-50%
3
Q
Myelofibrosis
A
Fibrotic obliteration of bone marrow; teardrop cell
Decreased RBCs, variable WBCs, Variable platelets; positive JAK2 mutation in 30-50%
4
Q
CML
A
Decreased RBCs, Increased
bcr-abl transformation leads to increased cell division and inhibition of apoptosis
WBCs, Increased platelets; positive philadelphia chromosome; negative JAK2 mutation