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Flashcards in Teratogens Deck (19):
1

ACE inhibitors

renal damage

2

Alkylating agents

absence of digits, multiple anomalies

3

Aminoglycosides

CN VIII toxicity

4

Carbamazepine

neural tube defects, craniofacial defects, fingernail hypoplasia, developmental delay, IUGR

5

Diethylstilbestrol

vaginal clear cell adenocarcinoma, congenital Mullerian anomalies

6

Folate antagonists

neural tube defects

7

Lithium

Ebstein's anomaly (atrialize right ventricle)

8

Phenytoin

fetal hydantoin syndrome: microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, mental retardation

9

Tetracyclines

discolored teeth

10

Thalidomide

limb defects (flipper limbs)

11

Valproate

inhibition of maternal folate absorption --> neural tube defects

12

Warfarin

bone deformities, fetal hemorrhage, abortion, opthalmologic abnormalities

13

Alcohol

leading cause of birth defects and mental retardation; fetal alcohol syndrome

14

Cocaine

abnormal fetal development and fetal addiction; placental abruption

15

Smoking (nicotine, CO)

preterm labor, placental problems, IUGR, ADHD

16

Iodide (lack or excess)

congenital goiter or hypothyroidism (cretinism)

17

Maternal diabetes

caudal regression syndrome (anal atresia to sirenomelia), congenital heart defects, neural tube defects

18

Vitamin A (excess)

extremely high risk for spontaneous abortions and birth defects (cleft palate, cardiac abnormalities)

19

X-rays

microcephaly, mental retardation

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