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Flashcards in Tumor Markers Deck (12):
1

PSA

Prostate-specific antigen. Used to follow prostate carcinoma. Can also be elevated in BPH and prostatitis. Questionable risk/benefit for screening.

Tumor markers should not be used as the 1 degree tool for cancer diagnosis. They may be used to confirm diagnosis, to monitor for tumor recurrence, and to monitor response to therapy.

2

Prostatic acid phosphatase

Prostate carcinoma.

3

CEA

CarcinoEmbryonic Antigen. Very nonspecific but produced by approximately 70% of colorectal and pancreatic cancers; also produced by gastric, breast, and medullary thyroid carcinomas.

4

Alpha-fetoprotein

Normally made by fetus. Hepatocellular carcinomas. Nonsemiomatous germ cell tumors (e.g., testis, ovary).

5

Beta-hCG

Hydatidiform moles and Choriocarcinomas (Gestational trophoblastic disease).

hCG is commonly associated with pregnancy.

6

CA-125

Ovarian cancer.

7

S-100

Melanoma, neural tumors, schwannomas.

8

Alkaline phosphatase

Metastases to bone, liver, Paget's disease of bone.

9

Bombesin

Neuroblastoma, lung and gastric cancer.

10

TRAP

Tartrate-Resistant Acid Aphophatase (TRAP).
Hairy cell leukemia - a B-cell neoplasm.

TRAP the hairy animal.

11

CA-19-9

Pancreatic adenocarcinoma.

12

Calcitonin

Medullary thyroid carcinoma.

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