Flashcards in Tumor Markers Deck (12):
Prostate-specific antigen. Used to follow prostate carcinoma. Can also be elevated in BPH and prostatitis. Questionable risk/benefit for screening.
Tumor markers should not be used as the 1 degree tool for cancer diagnosis. They may be used to confirm diagnosis, to monitor for tumor recurrence, and to monitor response to therapy.
Prostatic acid phosphatase
CarcinoEmbryonic Antigen. Very nonspecific but produced by approximately 70% of colorectal and pancreatic cancers; also produced by gastric, breast, and medullary thyroid carcinomas.
Normally made by fetus. Hepatocellular carcinomas. Nonsemiomatous germ cell tumors (e.g., testis, ovary).
Hydatidiform moles and Choriocarcinomas (Gestational trophoblastic disease).
hCG is commonly associated with pregnancy.
Melanoma, neural tumors, schwannomas.
Metastases to bone, liver, Paget's disease of bone.
Neuroblastoma, lung and gastric cancer.
Tartrate-Resistant Acid Aphophatase (TRAP).
Hairy cell leukemia - a B-cell neoplasm.
TRAP the hairy animal.