Complement Disorders

Question 1

C1 esterase inhibitor deficiency

Answer 1

-> hereditary angioedema. ACE inhibitors are contraindicated.

Question 2

C3 deficiency

Answer 2

-> severe, recurrent pyogenic sinus and respiratory tract infections. Increased susceptibility to type III hypersensitivity reactions.

Question 3

C5-C9 deficiencies

Answer 3

-> recurrent Neisseria bacteremia.

Question 4

DAF (GPI anchored enzyme) deficiency

Answer 4

-> complement-mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria (PNH).