Drug reactions Flashcards Preview

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Flashcards in Drug reactions Deck (44):
1

coronary vasospasm

cocaine, sumatriptan, ergot alkaloids

2

cutaneous flushing

vancomycin, adenosine, niacin, Ca channel blockers (VANC)

3

dilated cardiomyopathy

doxorubicin (adriamycin), daunorubicin

4

torsades de pointes

Class III (sotalol), and class IA (quinidine) antiarrhythmics

5

agranulocytosis

clozapine, carbamazepine, colchicine, propylthiouracil, methimazole, dapsone

6

aplastic anemia

chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

7

direct Coombs-positive hemolytic anemia

methyldopa, penicillin

8

gray baby syndrome

chloramphenicol

9

hemolysis in G6PD deficient patients

isoniazid (INH), sulfonamides, primaquine, aspirin, ibuprofen, nitrofurantoin (hemolysis IS PAIN)

10

megaloblastic anemia

phenytoin, methotrexate, sulfa drugs

11

thrombotic complications

OCPs

12

Cough

ACE inhibitors

13

Pulmonary fibrosis

Bleomycin, Amiodarone, busulfan

14

Acute cholestatic hepatitis, jaundice

erythromycin

15

focal to massive hepatic necrosis

halothane, amantita phalloides, valproic acid, acetaminophen

16

hepatitis

INH

17

pseudomembranous colitis

clindamycin, ampicillin

18

adenocortical insufficiency

glucocorticoid withdrawal (HPA suppression)

19

gynecomastia

spironolactone, digitalis, cimetidine, chronic alcohol use, estrogens, ketoconazole (Some Drugs Create Awkward Knockers)

20

Hot flashes

Tamoxifen, clomiphene

21

Hyperglycemia

niacin, tacrolimus, protease inhibitors, HCTZ, corticosteroids

22

Hypothyroidism

Lithium, amiodarone, sulfonamides

23

Fat redistribution

Glucocorticoids, protease inhibitors

24

Gingival hyperplasia

Phenytoin, verapamil

25

Gout

Furosemide, thiazides, niacin, cyclosporine

26

Myopathies

Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon-alpha, Penicillamine, Statins, Glucocorticoids

27

Osteoporosis

corticosteroids, heparin

28

Photosensitivity

sulfonamides, amiodarone, tetracycline

29

Rash (stevens-johnson syndrome)

Penicillin, ethosuximide, carbamazepine, sulfa drugs, lamotrigine, allopurinol, phenytoin, phenobarbital

30

SLE-like syndrome

Hydralazine, INH, Procainamide, Phenytoin

31

Teeth (kids)

Tetracyclines

32

Tendonitis, tendon rupture and cartilage damage

Fluoroquinolones

33

Diabetes insipidus

Lithium, democlocycline

34

Fanconi's syndrome

Expired tetracycline

35

Hemorrhagic cystitis

Cyclophosphamide, ifosfamide (prevent by coadministering with mesna)

36

Interstitial nephritis

Methicillin, NSAIDs, furosemide

37

SIADH

carbamazepine, cyclophosphamide

38

Cinchonism

quinidine, quinine

39

Parkinson-like syndrome

antipsychotics, reserpine, metoclopramide

40

Seizures

Isoniazid, Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide

41

Tardive dyskinesia

antipsychotics

42

Antimuscurinic

Atropine, TCAs, H1-blockers, neuroleptics

43

Disulfiram-like reaction

Metronidazole, certain cephalosporins, procarbazine, 1st-generation sulfonylureas

44

Nephrotoxicity/ototoxicity

aminoglycosides, vancomycin, loop diuretics, cisplatin

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